U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PDCD-5 Programmed Cell Death 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39776, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PDCD-5provided by FlyBase
    Official Full Name
    Programmed Cell Death 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0036580
    Locus tag
    Dmel_CG13072
    See related
    AllianceGenome:FB:FBgn0036580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE17056; CG13072; Dmel\CG13072; DMPDCD-5; PDCD5
    Summary
    Predicted to enable DNA binding activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; trunk mesoderm; and visceral muscle primordium. Orthologous to human PDCD5 (programmed cell death 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PDCD-5 in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16231081..16232038, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16224181..16225138, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Methionine-CAT 1-3 Neighboring gene lethal (3) 72Dn Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Mediator complex subunit 10 Neighboring gene Heat shock protein cognate 20 Neighboring gene lethal (3) 72Dp

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. Pirooznia SK, et al. PLoS One, 2012. PMID 22848598, Free PMC Article
    2. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    3. Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model. Stephano F, et al. Sci Rep, 2018 Feb 5. PMID 29403026, Free PMC Article
    4. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
    5. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Cronin SJ, et al. Science, 2009 Jul 17. PMID 19520911, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of innate immune response HMP PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    programmed cell death 5
    Names
    CG13072-PA
    PDCD-5-PA
    programmed cell death gene-5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16231081..16232038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140591.4 → NP_648848.1  programmed cell death 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUZ8
      Related
      FBpp0075238
      Conserved Domains (1) summary
      pfam01984
      Location:9 → 104
      dsDNA_bind; Double-stranded DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUZ8 Q9VUZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools