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    eIF5B eukaryotic translation initiation factor 5B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF5Bprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 5Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026259
    Locus tag
    Dmel_CG10840
    See related
    AllianceGenome:FB:FBgn0026259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A1; anon-WO0118547.362; CG10840; CG14970; cIF2; dIF2; Dmel\CG10840; Eif5b; EIF5B; IF2; yIF2
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Is expressed in adult brain cell body rind and adult head. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF5B in Genome Data Viewer
    Location:
    63E1-63E1; 3-8 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3428658..3460977, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3428658..3460977, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45737 Neighboring gene sprouty Neighboring gene mir-2282 stem loop Neighboring gene uncharacterized protein Neighboring gene armitage Neighboring gene uncharacterized protein Neighboring gene Cyclin J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa. Linder P, et al. Cell, 2006 Apr 21. PMID 16630807
    2. VASA mediates translation through interaction with a Drosophila yIF2 homolog. Carrera P, et al. Mol Cell, 2000 Jan. PMID 10678180
    3. The DEAD-box helicase Vasa: evidence for a multiplicity of functions in RNA processes and developmental biology. Lasko P. Biochim Biophys Acta, 2013 Aug. PMID 23587717
    4. Interaction with eIF5B is essential for Vasa function during development. Johnstone O, et al. Development, 2004 Sep. PMID 15280213
    5. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. interaction with the general translation factor eIF5B is essential for Vas function during development
      Title: Interaction with eIF5B is essential for Vasa function during development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5B
    Names
    CG10840-PB
    CG10840-PC
    CG10840-PD
    CG10840-PE
    CG10840-PF
    cytoplasmic initiation factor 2
    eIF5B-PB
    eIF5B-PC
    eIF5B-PD
    eIF5B-PE
    eIF5B-PF
    eukaryotic initiation factor 5B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3428658..3460977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259672.2 → NP_001246601.1  eukaryotic translation initiation factor 5B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND37, R4TCQ6
      Conserved Domains (5) summary
      cd01887
      Location:557 → 769
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:553 → 1093
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:890 → 993
      IF-2; Translation-initiation factor 2
      cd03703
      Location:779 → 889
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cl02787
      Location:1016 → 1074
      Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins

    2. NM_001259671.2 → NP_001246600.1  eukaryotic translation initiation factor 5B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFL1, R4TCQ6
      Conserved Domains (5) summary
      cd01887
      Location:557 → 769
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      pfam00009
      Location:558 → 765
      GTP_EFTU; Elongation factor Tu GTP binding domain
      pfam11987
      Location:890 → 993
      IF-2; Translation-initiation factor 2
      cd03703
      Location:779 → 889
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cl02787
      Location:1016 → 1053
      Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins

    3. NM_001259670.2 → NP_001246599.1  eukaryotic translation initiation factor 5B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZP5, R4TCQ6
      Conserved Domains (5) summary
      cd01887
      Location:557 → 769
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:553 → 1129
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:890 → 993
      IF-2; Translation-initiation factor 2
      cd03703
      Location:779 → 889
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:1016 → 1110
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

    4. NM_001259673.2 → NP_001246602.1  eukaryotic translation initiation factor 5B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZP5, R4TCQ6
      Conserved Domains (5) summary
      cd01887
      Location:557 → 769
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:553 → 1129
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:890 → 993
      IF-2; Translation-initiation factor 2
      cd03703
      Location:779 → 889
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:1016 → 1110
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

    5. NM_143717.3 → NP_651974.1  eukaryotic translation initiation factor 5B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZP5, R4TCQ6
      Related
      FBpp0073003
      Conserved Domains (5) summary
      cd01887
      Location:557 → 769
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:553 → 1129
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:890 → 993
      IF-2; Translation-initiation factor 2
      cd03703
      Location:779 → 889
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:1016 → 1110
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND37 M9ND37
    M9NFL1 M9NFL1
    Q9NJH7 Q9NJH7
    Q9VZP5 Q9VZP5

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