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    CG5554 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5554provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034914
    Locus tag
    Dmel_CG5554
    See related
    AllianceGenome:FB:FBgn0034914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5554
    Summary
    Predicted to enable protein-disulfide reductase activity. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5554 in Genome Data Viewer
    Location:
    60A3-60A3; 2-105 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23845001..23847024)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19732524..19734547)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene shutdown Neighboring gene Synaptosomal-associated protein 29kDa Neighboring gene yantar Neighboring gene antisense RNA:CR45928 Neighboring gene eukaryotic translation initiation factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Clissold PM, et al. Bioessays, 2003 Jun. PMID 12766950
    2. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Fan W, et al. PLoS Genet, 2017 Mar. PMID 28273089, Free PMC Article
    3. Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. Yatsenko AS, et al. BMC Med, 2020 Jan 21. PMID 31959160, Free PMC Article
    4. Stem Cell-Intrinsic, Seven-up-Triggered Temporal Factor Gradients Diversify Intermediate Neural Progenitors. Ren Q, et al. Curr Biol, 2017 May 8. PMID 28434858
    5. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5554-PA
    CG5554-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23845001..23847024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299855.1 → NP_001286784.1  uncharacterized protein Dmel_CG5554, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHC9
      Conserved Domains (1) summary
      cd02994
      Location:36 → 136
      PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

    2. NM_137994.3 → NP_611838.1  uncharacterized protein Dmel_CG5554, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1I7
      Related
      FBpp0072035
      Conserved Domains (1) summary
      cd02994
      Location:36 → 136
      PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHC9 A0A0B4LHC9
    Q9W1I7 Q9W1I7

    Gene LinkOut

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