Blos1 Biogenesis of lysosome-related organelles complex 1, subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Blos1provided by FlyBase
Official Full Name: Biogenesis of lysosome-related organelles complex 1, subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0050077
Locus tag: Dmel_CG30077
See related: AllianceGenome:FB:FBgn0050077
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: blos1; BLOS1; CG10127; CG30077; Dmel\CG30077; NP_725401
Summary: Involved in several processes, including neuromuscular synaptic transmission; olfactory learning; and vesicle organization. Part of BLOC-1 complex. Is active in neuromuscular junction. Used to study Hermansky-Pudlak syndrome; metal metabolism disorder; and schizophrenia. Orthologous to human BLOC1S1 (biogenesis of lysosomal organelles complex 1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14601278..14602010)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10488783..10489515)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Blos-1 was confirmed to be present in neurons and Blos-1 perturbation changed synaptic output and function.
Title: Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling via endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	IEA Inferred from Electronic Annotation more info
part_of BLOC-1 complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Preferred Names: biogenesis of lysosome-related organelles complex 1, subunit 1

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