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    CG9265 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9265provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032910
    Locus tag
    Dmel_CG9265
    See related
    AllianceGenome:FB:FBgn0032910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9265; HSD17B11
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be active in lipid droplet. Is expressed in adult brain; adult head; and organism. Orthologous to several human genes including SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9265 in Genome Data Viewer
    Location:
    39A1-39A1; 2-54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21057706..21071502, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21057706..21071502, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44606 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Integrin betanu subunit Neighboring gene uncharacterized protein Neighboring gene torn and diminished rhabdomeres

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular signature of BCR::ABL(P210) and BCR::ABL(T315I) in a Drosophila melanogaster chronic myeloid leukemia model. Baassiri A, et al. iScience, 2024 Apr 19. PMID 38585663, Free PMC Article
    2. Context-dependent genetic architecture of Drosophila life span. Huang W, et al. PLoS Biol, 2020 Mar. PMID 32134916, Free PMC Article
    3. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Koh TW, et al. Neuron, 2004 Jul 22. PMID 15260956
    4. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article
    5. The genetics of egg retention and fertilization success in Drosophila: One step closer to understanding the transition from facultative to obligate viviparity. Horváth B, et al. Evolution, 2018 Feb. PMID 29265369

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9265-PA
    CG9265-PB
    CG9265-PC
    CG9265-PD
    NP_001260655.1
    NP_001260656.1
    NP_001260657.1
    NP_610081.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21057706..21071502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273726.1 → NP_001260655.1  uncharacterized protein Dmel_CG9265, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYX3, Q9VIG6
      Conserved Domains (2) summary
      cd05339
      Location:88 → 328
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK05653
      Location:82 → 299
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    2. NM_001273727.1 → NP_001260656.1  uncharacterized protein Dmel_CG9265, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYX3, Q9VIG6
      Conserved Domains (2) summary
      cd05339
      Location:88 → 328
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK05653
      Location:82 → 299
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    3. NM_001273728.1 → NP_001260657.1  uncharacterized protein Dmel_CG9265, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYX3, Q9VIG6
      Conserved Domains (2) summary
      cd05339
      Location:88 → 328
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK05653
      Location:82 → 299
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    4. NM_136237.4 → NP_610081.3  uncharacterized protein Dmel_CG9265, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610081.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYX3, Q9VIG6
      Conserved Domains (2) summary
      cd05339
      Location:88 → 328
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK05653
      Location:82 → 299
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYX3 Q8SYX3
    Q9VIG6 Q9VIG6

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