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    Nepl8 Neprilysin-like 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl8provided by FlyBase
    Official Full Name
    Neprilysin-like 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0032585
    Locus tag
    Dmel_CG4580
    See related
    AllianceGenome:FB:FBgn0032585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4580; Dmel\CG4580
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl8 in Genome Data Viewer
    Location:
    36A2-36A2; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16488148..16490182)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16488148..16490182)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Imaginal disc growth factor 3 Neighboring gene dachshund Neighboring gene long non-coding RNA:CR44994 Neighboring gene Tetratricopeptide repeat protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Pappu KS, et al. Development, 2005 Jun. PMID 15930118
    2. Tools for neuroanatomy and neurogenetics in Drosophila. Pfeiffer BD, et al. Proc Natl Acad Sci U S A, 2008 Jul 15. PMID 18621688, Free PMC Article
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    5. Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. Jakobsen JS, et al. Genes Dev, 2007 Oct 1. PMID 17908931, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 8
    Names
    CG4580-PA
    Nepl8-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16488148..16490182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135951.4 → NP_609795.2  Neprilysin-like 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609795.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJK5
      Related
      FBpp0080422
      Conserved Domains (1) summary
      cl14813
      Location:32 → 618
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJK5 Q9VJK5

    Gene LinkOut

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