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    PLCXD Phosphatidylinositol-specific phospholipase C X domain containing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PLCXDprovided by FlyBase
    Official Full Name
    Phosphatidylinositol-specific phospholipase C X domain containingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032402
    Locus tag
    Dmel_CG14945
    See related
    AllianceGenome:FB:FBgn0032402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg14945; CG14945; Dmel\CG14945; dPLCXD
    Summary
    Predicted to enable phosphoric diester hydrolase activity. Involved in endosome organization. Located in endosome membrane. Is expressed in several structures, including embryonic hindgut; embryonic large intestine; embryonic/larval garland cell; spermatozoon; and ventral midline of embryo. Orthologous to human PLCXD1 (phosphatidylinositol specific phospholipase C X domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PLCXD in Genome Data Viewer
    Location:
    33B11-33B11; 2-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12049418..12052049)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12049418..12052049)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44589 Neighboring gene Promyelocytic leukemia zinc finger Neighboring gene Juvenile hormone Inducible-21 Neighboring gene Ribosomal protein L7-like Neighboring gene uncharacterized protein Neighboring gene Rab3 GTPase activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PTEN reduces endosomal PtdIns(4,5)P(2) in a phosphatase-independent manner via a PLC pathway. Mondin VE, et al. J Cell Biol, 2019 Jul 1. PMID 31118240, Free PMC Article
    2. The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae. Ziegler AB, et al. Sci Rep, 2016 Jan 25. PMID 26805723, Free PMC Article
    3. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF. Jensen LT, et al. Cell Stress Chaperones, 2008 Summer. PMID 18759003, Free PMC Article
    4. Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila. Hood SE, et al. J Lipid Res, 2020 Dec. PMID 32989002, Free PMC Article
    5. Differential gene expression in a tripartite interaction: Drosophila, Spiroplasma and parasitic wasps. Higareda Alvear VM, et al. PeerJ, 2021. PMID 33717711, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Phosphatidylinositol-specific phospholipase C X domain containing
    Names
    CG14945-PA
    CG14945-PB
    PLCXD-PA
    PLCXD-PB
    NP_609541.1
    NP_723716.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12049418..12052049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164987.2 → NP_723716.1  Phosphatidylinositol-specific phospholipase C X domain containing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC3
      Related
      FBpp0079878
      Conserved Domains (1) summary
      cd08622
      Location:202 → 479
      PI-PLCXDc_CG14945_like; Catalytic domain of Drosophila melanogaster CG14945-like proteins similar to phosphatidylinositol-specific phospholipase C, X domain containing

    2. NM_135697.2 → NP_609541.1  Phosphatidylinositol-specific phospholipase C X domain containing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609541.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKC3
      Related
      FBpp0079879
      Conserved Domains (1) summary
      cd08622
      Location:202 → 479
      PI-PLCXDc_CG14945_like; Catalytic domain of Drosophila melanogaster CG14945-like proteins similar to phosphatidylinositol-specific phospholipase C, X domain containing
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYW3 Q8MYW3
    Q9VKC3 Q9VKC3

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