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    Rchy1 Ring finger and CHY zinc finger domain containing 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rchy1provided by FlyBase
    Official Full Name
    Ring finger and CHY zinc finger domain containing 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031816
    Locus tag
    Dmel_CG16947
    See related
    AllianceGenome:FB:FBgn0031816
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey20; CG16947; Dmel\CG16947
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of gliogenesis. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in embryonic large intestine and yolk nucleus. Orthologous to human RCHY1 (ring finger and CHY zinc finger domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rchy1 in Genome Data Viewer
    Location:
    26D5-26D7; 2-20 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6459015..6465669, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6459015..6465669, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene real-time Neighboring gene farjavit Neighboring gene HemK methyltransferase 1 Neighboring gene mummy

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain. Foo LC, et al. EMBO J, 2017 May 2. PMID 28320737, Free PMC Article
    2. Cyclin-dependent kinase 9 is required for the survival of adult Drosophila melanogaster glia. Foo LC. Sci Rep, 2017 Jul 28. PMID 28754981, Free PMC Article
    3. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
    4. Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes. Francis D, et al. G3 (Bethesda), 2021 Sep 27. PMID 34568906, Free PMC Article
    5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ring finger and CHY zinc finger domain containing 1
    Names
    CG16947-PA
    CG16947-PB
    Rchy1-PA
    Rchy1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6459015..6465669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135186.2 → NP_609030.1  ring finger and CHY zinc finger domain containing 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMD4
      Related
      FBpp0078901
      Conserved Domains (3) summary
      cd00162
      Location:311 → 357
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam05495
      Location:184 → 257
      zf-CHY; CHY zinc finger
      pfam14599
      Location:358 → 416
      zinc_ribbon_6; Zinc-ribbon

    2. NM_001273204.2 → NP_001260133.1  ring finger and CHY zinc finger domain containing 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMD4
      Conserved Domains (3) summary
      cd00162
      Location:311 → 357
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam05495
      Location:184 → 257
      zf-CHY; CHY zinc finger
      pfam14599
      Location:358 → 416
      zinc_ribbon_6; Zinc-ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMD4 Q9VMD4

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