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    Decay Death executioner caspase related to Apopain/Yama [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42008, updated on 17-Dec-2024

    Summary

    Official Symbol
    Decayprovided by FlyBase
    Official Full Name
    Death executioner caspase related to Apopain/Yamaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028381
    Locus tag
    Dmel_CG14902
    See related
    AllianceGenome:FB:FBgn0028381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cas3; Cas3; CAS3; Casp-3; Casp3; Caspae-3; caspase 3; caspase-3; Caspase-3; CC-3; CC3; CG14902; decay; DECAY; Dmel\CG14902; Drosophila executioner caspase related to Apopain/Yama
    Summary
    Enables cysteine-type endopeptidase activity. Involved in apoptotic process. Located in cytoplasm. Is expressed in several structures, including adult head; egg chamber; female germline cell; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and neurodegenerative disease (multiple). Orthologous to human CASP3 (caspase 3) and CASP7 (caspase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Decay in Genome Data Viewer
    Location:
    89B18-89B18; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16499058..16501050, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12324780..12326772, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cadherin 89D Neighboring gene Gustatory receptor 89a Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46030 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in apoptotic process PubMed 
    NOT involved_in larval midgut histolysis PubMed 
    involved_in positive regulation of neuron apoptotic process  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 

    General protein information

    Preferred Names
    death executioner caspase related to Apopain/Yama
    Names
    CG14902-PA
    Caspase-3
    Caspase3
    Decay-PA
    caspase 3
    caspase-3 protein
    cleaved caspase 3
    decay
    NP_477462.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16499058..16501050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058114.4 → NP_477462.1  death executioner caspase related to Apopain/Yama [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHF9, Q9VET9
      Related
      FBpp0082755
      Conserved Domains (1) summary
      cd00032
      Location:54 → 302
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
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