didum dilute class unconventional myosin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: didumprovided by FlyBase
Official Full Name: dilute class unconventional myosinprovided by FlyBase
Primary source: FLYBASE:FBgn0261397
Locus tag: Dmel_CG2146
See related: AllianceGenome:FB:FBgn0261397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 43CD; CG2146; Didum; Dmel\CG2146; dmM5; DmV; M5; Myo1C; Myo5; myoV; MyoV; MYOV; MyoV43CD; NEST:bs14c05; NMC7; soy
Summary: Enables several functions, including ATP binding activity; calcium-dependent ATPase activity; and cytoskeletal protein binding activity. Involved in several processes, including positive regulation of pole plasm oskar mRNA localization; rhabdomere development; and sperm individualization. Located in neuronal cell body and rhabdomere. Part of myosin V complex. Is expressed in several structures, including adult head; embryonic/larval hindgut; female germline cell; and gonad. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1; microvillus inclusion disease; and progressive familial intrahepatic cholestasis. Orthologous to several human genes including MYO5A (myosin VA) and MYO5C (myosin VC). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43C7-43D1; 2-56 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7500147..7508625)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3387652..3396130)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Competition between kinesin-1 and myosin-V defines Drosophila posterior determination.
Title: Competition between kinesin-1 and myosin-V defines Drosophila posterior determination.
Patronin and Shot then act to polarise microtubules along the apical-basal axis to enable apical transport of Rab11 endosomes by the Nuf-Dynein microtubule motor complex. Finally, Rab11 endosomes are transferred to the MyoV (also known as Didum in Drosophila) actin motor to deliver the key microvillar determinant Cadherin 99C to the apical membrane to organise the biogenesis of actin microvilli.
Title: Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.
data indicate that myosin V and VI, but not II, play related but distinct roles in regulating microtubule (MT)-based mitochondrial movement: they oppose, rather than complement, protracted MT-based movements and perhaps facilitate organelle docking
Title: Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria.
the mechanical properties of coiled-coil regions of myosin v
Title: Extensibility of the extended tail domain of processive and nonprocessive myosin V molecules.
Data show that didum, encoding the Drosophila actin-based motor Myosin-V, is a new posterior group gene that promotes posterior accumulation of Oskar.
Title: Myosin-V regulates oskar mRNA localization in the Drosophila oocyte.
MyoV was associated with membranes, microtubule, and actin structures required for spermatid maturation.
Title: Drosophila myosin V is required for larval development and spermatid individualization.
Myosin V delivers morphogenic secretory traffic along polarized actin filaments of the subcortical terminal web to the exocytic plasma membrane target, the rhabdomere base.
Title: Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.
analysis of the motor mechanism of Drosophila Myosin V
Title: Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in anterior/posterior axis specification, embryo	HMP more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion transport along microtubule	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin V complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dilute class unconventional myosin

Names: CG2146-PA; CG2146-PB; CG2146-PC; Myosin5; MyosinV; didum; didum-PA; didum-PB; didum-PC; myosin V; myosin-5; myosin-V; shorty

NP_477186.1

EC 5.6.1.8

NP_724569.1

EC 5.6.1.8

NP_724570.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7500147..7508625

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057838.4 → NP_477186.1 dilute class unconventional myosin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477186.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6Z9, O97417

Related

FBpp0088686

Conserved Domains (7) summary

smart00015
Location:892 → 914

IQ; Calmodulin-binding motif

smart00242
Location:65 → 770

MYSc; Myosin. Large ATPases

cd15470
Location:1416 → 1784

Myo5_CBD; Cargo binding domain of myosin 5

cd01380
Location:84 → 759

MYSc_Myo5; class V myosin, motor domain

pfam16034
Location:1182 → 1291

JAKMIP_CC3; JAKMIP CC3 domain

cd16269
Location:1041 → 1060

GBP_C; coiled coil [structural motif]

cl20817
Location:963 → 1078

GBP_C; Guanylate-binding protein, C-terminal domain
NM_165535.2 → NP_724569.1 dilute class unconventional myosin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724569.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6Z8, U3R9T8

Related

FBpp0088684

Conserved Domains (7) summary

smart00015
Location:900 → 922

IQ; Calmodulin-binding motif

smart00242
Location:65 → 778

MYSc; Myosin. Large ATPases

cd15470
Location:1424 → 1792

Myo5_CBD; Cargo binding domain of myosin 5

cd01380
Location:84 → 767

MYSc_Myo5; class V myosin, motor domain

pfam16034
Location:1190 → 1299

JAKMIP_CC3; JAKMIP CC3 domain

cd16269
Location:1049 → 1068

GBP_C; coiled coil [structural motif]

cl20817
Location:971 → 1086

GBP_C; Guanylate-binding protein, C-terminal domain
NM_165536.3 → NP_724570.1 dilute class unconventional myosin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724570.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z700, Q7YU40

Related

FBpp0088685

Conserved Domains (5) summary

smart00015
Location:892 → 914

IQ; Calmodulin-binding motif

smart00242
Location:65 → 770

MYSc; Myosin. Large ATPases

cd01380
Location:84 → 759

MYSc_Myo5; class V myosin, motor domain

cd16269
Location:1041 → 1060

GBP_C; coiled coil [structural motif]

cl20817
Location:963 → 1078

GBP_C; Guanylate-binding protein, C-terminal domain