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    Irbp Inverted repeat-binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117419, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Irbpprovided by FlyBase
    Official Full Name
    Inverted repeat-binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011774
    Locus tag
    Dmel_CG5247
    See related
    AllianceGenome:FB:FBgn0011774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5247; Dmel\CG5247; DmKu70; dp70; irbp; IRBP; IRBP/Ku70; Ku; ku70; Ku70; Ku70/Ku80; p70; YPF1; Ypf1b; YPF1beta
    Summary
    Enables DNA binding activity. Involved in double-strand break repair via nonhomologous end joining and telomere maintenance. Part of Ku70:Ku80 complex. Is expressed in organism. Orthologous to human XRCC6 (X-ray repair cross complementing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Irbp in Genome Data Viewer
    Location:
    86E4-86E4; 3-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11410047..11412440)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7235769..7238162)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene merry-go-round Neighboring gene ncRNA Neighboring gene Importin 9 Neighboring gene brother of rumpel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DNA-dependent protein kinase. Smith GC, et al. Genes Dev, 1999 Apr 15. PMID 10215620
    2. Purification and properties of yolk protein factor I, a sequence-specific DNA-binding protein from Drosophila melanogaster. Mitsis PG, et al. J Biol Chem, 1989 Mar 25. PMID 2494182
    3. Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. Tamura T, et al. PLoS One, 2011. PMID 22096569, Free PMC Article
    4. Identification and purification of a Drosophila protein that binds to the terminal 31-base-pair inverted repeats of the P transposable element. Rio DC, et al. Proc Natl Acad Sci U S A, 1988 Dec. PMID 2848246, Free PMC Article
    5. Autoantigen Ku and its role in multiple cellular processes. Ghosh AK. Indian J Exp Biol, 1997 Dec. PMID 9567759

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results collectively support that Ku70 is a critical mediator of the HD pathology and a candidate therapeutic target in HD.
      Title: Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.
    2. Role for Ku subunits in the regulation of sperm individualization.
      Title: Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells.
    3. Decrease in gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion.
      Title: The Ku protein complex is involved in length regulation of Drosophila telomeres.
    4. Coding sequence of Ku70 gene is wild-type in two mus309 mutant lines.
      Title: The Drosophila melanogaster Ku70 coding sequence is wild-type in mus309 mutants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ku70:Ku80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ku70:Ku80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inverted repeat-binding protein
    Names
    CG5247-PA
    CG5247-PB
    Irbp-PA
    Irbp-PB
    yolk protein factor 1b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11410047..11412440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080512.5 → NP_536773.1  inverted repeat-binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIF6, B6UVU9, B6UVV0, B6UVV1, B6UVV2, B6UVV3, B6UVV4, B6UVV5, B6UVV6, B6UVV7, B6UVV8, B6UVV9, B6UVW0, B6UVW2, B6UVW3, B6UVW4, Q23976, Q24006, Q8SYY3, Q9VGP5
      UniProtKB/TrEMBL
      L0CQ48, L0CRV4
      Related
      FBpp0081861
      Conserved Domains (3) summary
      cd00788
      Location:255 → 546
      KU70; Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      pfam12949
      Location:593 → 624
      HeH; HeH/LEM domain
      pfam03731
      Location:33 → 256
      Ku_N; Ku70/Ku80 N-terminal alpha/beta domain

    2. NM_001275545.1 → NP_001262474.1  inverted repeat-binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFM4
      Conserved Domains (1) summary
      pfam03731
      Location:33 → 257
      Ku_N; Ku70/Ku80 N-terminal alpha/beta domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFM4 A0A0B4KFM4
    Q23976.3 Q23976

    Gene LinkOut

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