Hsp83 Heat shock protein 83 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp83provided by FlyBase
Official Full Name: Heat shock protein 83provided by FlyBase
Primary source: FLYBASE:FBgn0001233
Locus tag: Dmel_CG1242
See related: AllianceGenome:FB:FBgn0001233
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 143198_at; 83; 83K HSP; anon-EST:Liang-2.53; anon-WO0068693; anon-WO0140519.209; CG1242; clone 2.53; dHsp90; Dmel\CG1242; DMHSP82; DmHsp83; E(sev)3A; E(sina)2; en(lz)3C/4C; hsp82; Hsp82; HSP82; hsp83; HSP83; hsp84; hsp90; Hsp90; HSP90; HSP90A1; l(3)j5C2; ms(3)08445; ORF1; P02828; stc; Su(Raf)3A
Summary: Enables TPR domain binding activity; insulin receptor binding activity; and unfolded protein binding activity. Involved in several processes, including cold acclimation; multivesicular body fusion to apical plasma membrane; and protein-containing complex assembly. Located in centrosome; perinuclear region of cytoplasm; and polytene chromosome interband. Part of protein folding chaperone complex. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; germline cell; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 63B11-63B11; 3-6 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3192969..3197059)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3192969..3197059)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
Title: Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
Title: Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
Plk4 Is a Novel Substrate of Protein Phosphatase 5.
Title: Plk4 Is a Novel Substrate of Protein Phosphatase 5.
Overexpression of Hsp83 in grossly depleted hsromega lncRNA background causes synthetic lethality and l(2)gl phenocopy in Drosophila.
Title: Over-expression of Hsp83 in grossly depleted hsrω lncRNA background causes synthetic lethality and l(2)gl phenocopy in Drosophila.
Hsp83 plays an essential role in germline stem cells self-renewal.
Title: Hsp83 regulates the fate of germline stem cells in Drosophila ovary.
Hsp83 functions upstream of the InR/PI3K/Akt pathway during neural stem cell reactivation.
Title: Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation.
Hsp90 binds close to the transcriptional start site of around one-third of all Drosophila coding genes.
Title: Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90).
The zymogen pro-Dcp-1 was found to interact with Hsp83 and undergo proteasomal regulation in an Hsp83-dependent manner.
Title: Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy.
Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs
Title: Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs.
Nup358 facilitates JH-induced Met nuclear transport in a manner dependent on importin beta and Hsp83.
Title: Nucleoporin Nup358 facilitates nuclear import of Methoprene-tolerant (Met) in an importin β- and Hsp83-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables TPR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RISC complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in RISC complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cold acclimation	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane bending	IDA Inferred from Direct Assay more info	PubMed
involved_in multivesicular body fusion to apical plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pole plasm mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	TAS Traceable Author Statement more info	PubMed
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
part_of protein folding chaperone complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 83

Names: CG1242-PA; CG1242-PB; Hsp83-PA; Hsp83-PB; enhancer of seven in absentia 2; enhancer of sevenless 3A; heat-shock protein 90 kDa; hsp83; scratch

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

3192969..3197059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274433.1 → NP_001261362.1 heat shock protein 83, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261362.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02828, P92174, P92202, Q9VZT3

UniProtKB/TrEMBL

M9PBL3

Conserved Domains (3) summary

smart00387
Location:28 → 179

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:6 → 717

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:184 → 706

HSP90; Hsp90 protein
NM_079175.4 → NP_523899.1 heat shock protein 83, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523899.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02828, P92174, P92202, Q9VZT3

UniProtKB/TrEMBL

M9PBL3

Related

FBpp0072904

Conserved Domains (3) summary

smart00387
Location:28 → 179

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:6 → 717

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:184 → 706

HSP90; Hsp90 protein