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    dec defective chorion [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    decprovided by FlyBase
    Official Full Name
    defective chorionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000427
    Locus tag
    Dmel_CG2175
    See related
    AllianceGenome:FB:FBgn0000427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    39051; CG2175; dec-1; dec1; dec[[1]]; Dmel\CG2175; Fc; Fc1; Fcp7C; fs(1)11-549; fs(1)12-1873; fs(1)12-2514; fs(1)12-3512; fs(1)12-365; fs(1)12-3907; fs(1)12-403; fs(1)12-4860; fs(1)13-453; fs(1)13C-57; fs(1)13C-73; fs(1)14-963; fs(1)14A-114; fs(1)14E19; fs(1)1501; fs(1)384; fs(1)5; fs(1)A257; fs(1)A384; fs(1)C1; fs(1)M102; fs(1)M1021
    Summary
    A structural constituent of egg chorion. Involved in chorion-containing eggshell formation and egg chorion assembly. Located in egg chorion. Is expressed in adult head; egg chamber; and follicle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dec in Genome Data Viewer
    Location:
    7C1-7C1; 1-21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7867161..7873222, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7761194..7767255, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 7b Neighboring gene antisense RNA:CR43615 Neighboring gene Ionotropic receptor 7c Neighboring gene Ionotropic receptor 7d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the dec-1 eggshell locus in Drosophila. II. Intraspecific DNA sequence analysis reveals length mutations in a repetitive region in D. melanogaster. Andersson S, et al. J Mol Evol, 1993 Jun. PMID 8350348
    2. fc177, a minor dec-1 proprotein, is necessary to prevent ectopic aggregation of the endochorion during eggshell assembly in Drosophila. Mauzy-Melitz D, et al. Dev Biol, 2003 Mar 15. PMID 12648483
    3. Aplysia capsulin is localized to egg capsules and egg cordon sheaths and shares sequence homology with Drosophila dec-1 gene products. Cummins SF, et al. Peptides, 2005 Apr. PMID 15752572
    4. Drosophila dec-1 eggshell proteins are differentially distributed via a multistep extracellular processing and localization pathway. Noguerón MI, et al. Dev Biol, 2000 Sep 15. PMID 10985863
    5. Multiple proteins are produced from the dec-1 eggshell gene in Drosophila by alternative RNA splicing and proteolytic cleavage events. Waring GL, et al. Dev Biol, 1990 Nov. PMID 1699826

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dominant female sterility was not associated with larger deletions that included the fc106 N terminus, suggesting that abnormal juxtaposition of N- and C-terminal sequences in the aberrant proprotein interfered with endogenous DEC-1 proteins.
      Title: A mutant dec-1 transgene induces dominant female sterility in Drosophila melanogaster.
    2. Capsulin shared sequence homology with eggshell proteins encoded by the Drosophila dec-1 gene.
      Title: Aplysia capsulin is localized to egg capsules and egg cordon sheaths and shares sequence homology with Drosophila dec-1 gene products.
    3. Expression of a fc177 cDNA in dec-1 null mutants was sufficient to restore spaces within the endochorion layer. Fc177 may function as a scaffolding protein akin to those utilized in viral morphogenesis.
      Title: fc177, a minor dec-1 proprotein, is necessary to prevent ectopic aggregation of the endochorion during eggshell assembly in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of egg chorion IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of egg chorion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chorion-containing eggshell formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorion-containing eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorion-containing eggshell formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in egg chorion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg chorion assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in egg chorion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in egg chorion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    defective chorion
    Names
    CG2175-PA
    CG2175-PB
    CG2175-PC
    CG2175-PE
    CG2175-PF
    CG2175-PG
    dec-PA
    dec-PB
    dec-PC
    dec-PE
    dec-PF
    dec-PG
    defective chorion 1
    follicle cell protein 7C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7867161..7873222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258640.2 → NP_001245569.1  defective chorion, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NG31
      Conserved Domains (2) summary
      pfam04625
      Location:57 → 463
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam04626
      Location:803 → 933
      DEC-1_C; Dec-1 protein, C terminal region

    2. NM_001258641.1 → NP_001245570.1  defective chorion, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEA7
      Conserved Domains (2) summary
      pfam04625
      Location:57 → 463
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam04626
      Location:803 → 933
      DEC-1_C; Dec-1 protein, C terminal region

    3. NM_001258642.1 → NP_001245571.1  defective chorion, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE0, M9NEY9
      Conserved Domains (2) summary
      pfam04625
      Location:74 → 480
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam04626
      Location:820 → 946
      DEC-1_C; Dec-1 protein, C terminal region

    4. NM_167132.2 → NP_727202.1  defective chorion, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18169, Q8IRP1
      Related
      FBpp0071098
      Conserved Domains (2) summary
      pfam04625
      Location:74 → 480
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam04626
      Location:820 → 950
      DEC-1_C; Dec-1 protein, C terminal region

    5. NM_078517.3 → NP_511072.2  defective chorion, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511072.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18171, Q9W3P3
      Related
      FBpp0071097
      Conserved Domains (2) summary
      pfam04625
      Location:74 → 480
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam04626
      Location:820 → 950
      DEC-1_C; Dec-1 protein, C terminal region

    6. NM_167133.2 → NP_727203.1  defective chorion, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18170, P92153, P92154, Q24299, Q26309, Q26310, Q26311, Q8IRP0
      UniProtKB/TrEMBL
      D3PFE0
      Related
      FBpp0071099
      Conserved Domains (2) summary
      pfam04625
      Location:74 → 480
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam04626
      Location:825 → 950
      DEC-1_C; Dec-1 protein, C terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEA7 M9NEA7
    M9NEY9 M9NEY9
    M9NG31 M9NG31
    P18169.2 P18169
    P18170.2 P18170
    P18171.2 P18171

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