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    PIP5K59B Phosphatidylinositol 4-phosphate 5-kinase 59B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIP5K59Bprovided by FlyBase
    Official Full Name
    Phosphatidylinositol 4-phosphate 5-kinase 59Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034789
    Locus tag
    Dmel_CG3682
    See related
    AllianceGenome:FB:FBgn0034789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17281; CG3682; Dmel\CG3682; dpip5k; dPIP5K; dPIP5K59B; PI4P5K; PIP5K; PIP5K 59B; PIPK59B
    Summary
    Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Involved in several processes, including phototransduction, visible light; positive regulation of phosphatidylinositol biosynthetic process; and regulation of synaptic assembly at neuromuscular junction. Located in rhabdomere microvillus membrane. Is expressed in adult head; eye; and larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See PIP5K59B in Genome Data Viewer
    Location:
    59B4-59B4; 2-101 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22874769..22881436)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18762292..18768959)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene forkhead domain 59A Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45469 Neighboring gene ER membrane protein complex subunit 8/9 Neighboring gene YME1 like ATPase Neighboring gene asrij Neighboring gene GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphoinositides in membrane traffic at the synapse. Cremona O, et al. J Cell Sci, 2001 Mar. PMID 11228149
    2. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. Yadav S, et al. J Cell Sci, 2015 Sep 1. PMID 26203165, Free PMC Article
    3. Septins tune lipid kinase activity and PI(4,5)P(2) turnover during G-protein-coupled PLC signalling in vivo. Kumari A, et al. Life Sci Alliance, 2022 Jun. PMID 35277468, Free PMC Article
    4. Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release. Khuong TM, et al. Neuron, 2013 Mar 20. PMID 23522045
    5. Evidence of sinks and sources in the phospholipase C-activated PIP(2) cycle. Suratekar R, et al. FEBS Lett, 2018 Mar. PMID 29427502

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction, visible light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rhabdomere microvillus membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase 59B
    Names
    CG3682-PA
    CG3682-PE
    CG3682-PF
    CG3682-PH
    CG3682-PI
    CG3682-PJ
    PIP5K59B-PA
    PIP5K59B-PE
    PIP5K59B-PF
    PIP5K59B-PH
    PIP5K59B-PI
    PIP5K59B-PJ
    phosphatidylinositol 4-phosphate 5-kinase at 59B
    NP_001036566.4
    NP_001246471.1
    NP_001246472.1
    NP_001369113.1
    NP_611729.2
    NP_726262.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22874769..22881436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043101.4 → NP_001036566.4  phosphatidylinositol 4-phosphate 5-kinase 59B, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036566.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8Y1, Q8T0K5
      Conserved Domains (1) summary
      smart00330
      Location:104 → 473
      PIPKc; Phosphatidylinositol phosphate kinases

    2. NM_001382080.1 → NP_001369113.1  phosphatidylinositol 4-phosphate 5-kinase 59B, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q9L5
      Conserved Domains (1) summary
      cd17301
      Location:78 → 473
      PIPKc_PIP5KI; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type I phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinases (PIP5KI) and similar proteins

    3. NM_001259542.2 → NP_001246471.1  phosphatidylinositol 4-phosphate 5-kinase 59B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7E3, Q8T0K5
      Conserved Domains (1) summary
      smart00330
      Location:104 → 469
      PIPKc; Phosphatidylinositol phosphate kinases

    4. NM_166567.4 → NP_726262.2  phosphatidylinositol 4-phosphate 5-kinase 59B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726262.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0K5, Q9W1Y3
      Conserved Domains (1) summary
      smart00330
      Location:104 → 469
      PIPKc; Phosphatidylinositol phosphate kinases

    5. NM_001259543.2 → NP_001246472.1  phosphatidylinositol 4-phosphate 5-kinase 59B, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7M0, Q8T0K5
      Conserved Domains (1) summary
      smart00330
      Location:104 → 469
      PIPKc; Phosphatidylinositol phosphate kinases

    6. NM_137885.4 → NP_611729.2  phosphatidylinositol 4-phosphate 5-kinase 59B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611729.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0K5, Q9W1Y2
      Related
      FBpp0071811
      Conserved Domains (1) summary
      smart00330
      Location:104 → 469
      PIPKc; Phosphatidylinositol phosphate kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7E3 A0A0B4K7E3
    A0A0B4K7M0 A0A0B4K7M0
    A0A6M3Q9L5 A0A6M3Q9L5
    Q0E8Y1 Q0E8Y1
    Q8T0K5 Q8T0K5
    Q9W1Y2 Q9W1Y2
    Q9W1Y3 Q9W1Y3

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