U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    alpha-Est7 alpha-Esterase-7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40901, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    alpha-Est7provided by FlyBase
    Official Full Name
    alpha-Esterase-7provided by FlyBase
    Primary source
    FLYBASE:FBgn0015575
    Locus tag
    Dmel_CG1112
    See related
    AllianceGenome:FB:FBgn0015575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aE7; ali; Ali; alpha est7; alpha-EST7; Alpha-Est7; alphaE7; alphaest-7; alphaEst7; CG1112; DmalphaE7; Dmel\CG1112; Est-23; Est23; EST23; H; Mce
    Summary
    Enables carboxylesterase activity. Involved in determination of adult lifespan; lipid storage; and response to organophosphorus. Is expressed in several structures, including adult head; adult heart; embryonic hindgut; embryonic/larval crystal cell; and fat body. Orthologous to human CES3 (carboxylesterase 3) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See alpha-Est7 in Genome Data Viewer
    Location:
    84D9-84D9; 3-48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7519563..7523753, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3345285..3349475, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-8 Neighboring gene Ubiquitin conjugating enzyme 84D Neighboring gene alpha-Esterase-6 Neighboring gene pseudo Neighboring gene Rtnl2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hydrolysis of pyrethroids by carboxylesterases from Lucilia cuprina and Drosophila melanogaster with active sites modified by in vitro mutagenesis. Heidari R, et al. Insect Biochem Mol Biol, 2005 Jun. PMID 15857765
    2. A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina. Spackman ME, et al. Biochem Genet, 1994 Feb. PMID 8031294
    3. Biochemical and physiological studies of soluble esterases from Drosophila melanogaster. Healy MJ, et al. Biochem Genet, 1991 Aug. PMID 1747098
    4. Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides. Hamby KA, et al. PLoS One, 2013. PMID 23861907, Free PMC Article
    5. Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway. Beaver LM, et al. Toxicol Sci, 2010 Jun. PMID 20348229, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-Est7 gene is not essential for Drosophila development but serves important functions for insecticide tolerance, lipid metabolism and lifespan control.
      Title: Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to organophosphorus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-Esterase-7
    Names
    CG1112-PA
    aliesterase
    aliesteraseless
    alpha-Est7-PA
    carboxylesterase 23
    esterase 23
    fragment H
    malathion carboxylesterase
    NP_524261.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7519563..7523753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079537.4 → NP_524261.1  alpha-Esterase-7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24201, Q9VIB5
      Related
      FBpp0081074
      Conserved Domains (2) summary
      COG0657
      Location:116 → 221
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:27 → 514
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24201 Q24201
    Q8IH63 Q8IH63
    Q9VIB5 Q9VIB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools