ex expanded [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: exprovided by FlyBase
Official Full Name: expandedprovided by FlyBase
Primary source: FLYBASE:FBgn0004583
Locus tag: Dmel_CG4114
See related: AllianceGenome:FB:FBgn0004583
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1270; brl; CG4114; Dmel\CG4114; Ex; EX; exp; Expanded; Frmd6; l(2)01270; l(2)ey
Summary: Enables DNA-binding transcription factor binding activity; kinase binding activity; and protein sequestering activity. Involved in several processes, including border follicle cell migration; negative regulation of developmental growth; and regulation of intracellular signal transduction. Located in apicolateral plasma membrane; cytoplasmic side of apical plasma membrane; and subapical part of cell. Part of Kibra-Ex-Mer complex. Colocalizes with cell-cell junction. Is expressed in several structures, including adult tracheal system; cuboidal/columnar epithelium; embryonic/larval optic lobe; gland; and imaginal disc. Used to study cancer. Orthologous to several human genes including FRMD1 (FERM domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 21C2-21C2; 2-0.7 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (431227..448701)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (431227..448701)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.
Title: Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.
Merlin and expanded integrate cell signaling that regulates cyst stem cell proliferation in the Drosophila testis niche.
Title: Merlin and expanded integrate cell signaling that regulates cyst stem cell proliferation in the Drosophila testis niche.
Here, the authors show that the Casein Kinase 1 (CKI) family is required for Expanded phosphorylation. CKI expression promotes Expanded phosphorylation and interaction with Slimb/beta-TrCP.
Title: Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.
study suggests that a complex pattern of ex transcription results from integration of a uniform SWH signal with multiple other inputs, rather than from a pattern of SWH signaling.
Title: Spatial regulation of expanded transcription in the Drosophila wing imaginal disc.
Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.
Title: Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.
results show that Zyxin is a functional antagonist of Expanded in growth control
Title: Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth.
The Ex-regulatory domain of Crb maps to the juxtamembrane FERM-binding motif (JM), a cytoskeletal interaction domain distinct from the PDZ-binding motif (PBM) through which Crb binds polarity factors.
Title: Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.
Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav.
Title: Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.
Mer and Ex signal through the Hippo pathway in Drosophila.
Title: The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.
new model whereby Expanded functions downstream of Warts, in concert with 14-3-3 proteins to sequester Yorkie in the cytoplasm, inhibiting growth activity of the Hippo pathway
Title: The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm1970 (e-PCR)
- UniSTS:35287

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in energy homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Kibra-Ex-Mer complex	IDA Inferred from Direct Assay more info	PubMed
part_of Kibra-Ex-Mer complex	IPI Inferred from Physical Interaction more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in subapical part of cell	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: expanded

Names: CG4114-PA; CG4114-PB; braille; ex-PA; ex-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

431227..448701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057492.4 → NP_476840.2 expanded, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476840.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q07436, Q9VPQ0

UniProtKB/TrEMBL

M9PC08

Related

FBpp0077719

Conserved Domains (5) summary

PHA03255
Location:512 → 681

PHA03255; BDLF3; Provisional

smart00295
Location:27 → 297

B41; Band 4.1 homologues

cd13185
Location:298 → 405

FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins

pfam00373
Location:132 → 305

FERM_M; FERM central domain

pfam09379
Location:40 → 98

FERM_N; FERM N-terminal domain
NM_001272894.1 → NP_001259823.1 expanded, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259823.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q07436, Q9VPQ0

UniProtKB/TrEMBL

M9PC08

Conserved Domains (5) summary

PHA03255
Location:512 → 681

PHA03255; BDLF3; Provisional

smart00295
Location:27 → 297

B41; Band 4.1 homologues

cd13185
Location:298 → 405

FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins

pfam00373
Location:132 → 305

FERM_M; FERM central domain

pfam09379
Location:40 → 98

FERM_N; FERM N-terminal domain