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    Gel Gelsolin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46008, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gelprovided by FlyBase
    Official Full Name
    Gelsolinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010225
    Locus tag
    Dmel_CG1106
    See related
    AllianceGenome:FB:FBgn0010225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1106; DGS; Dmel\CG1106; gel
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament polymerization; actin filament severing; and barbed-end actin filament capping. Located in actin filament; cytosol; and extracellular region. Is expressed in several structures, including adult head; adult heart; border follicle cell; embryonic/larval esophageal visceral muscle; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Finnish type amyloidosis and nephrotic syndrome type 21. Orthologous to several human genes including GSN (gelsolin) and SCIN (scinderin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gel in Genome Data Viewer
    Location:
    82A1-82A1; 3-47.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4235217..4241057)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (60939..66779)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene abstrakt Neighboring gene antisense RNA:CR46255 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleU

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of secreted and cytosolic gelsolin in Drosophila. Stella MC, et al. J Cell Biol, 1994 May. PMID 8175883, Free PMC Article
    2. Cloning of a secretory gelsolin from Drosophila melanogaster. Heintzelman MB, et al. J Mol Biol, 1993 Apr 5. PMID 8386771
    3. The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes. Yu CJ, et al. Int J Mol Sci, 2021 Dec 10. PMID 34948078, Free PMC Article
    4. The Drosophila gene abstrakt, required for visual system development, encodes a putative RNA helicase of the DEAD box protein family. Schmucker D, et al. Mech Dev, 2000 Mar 1. PMID 10704843
    5. α-synuclein impairs autophagosome maturation through abnormal actin stabilization. Sarkar S, et al. PLoS Genet, 2021 Feb. PMID 33556113, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes.
      Title: The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes.
    2. Gelsolin and dCryAB act downstream of muscle identity genes and contribute to preventing muscle splitting and branching in Drosophila.
      Title: Gelsolin and dCryAB act downstream of muscle identity genes and contribute to preventing muscle splitting and branching in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gelsolin
    Names
    CG1106-PA
    CG1106-PB
    CG1106-PD
    CG1106-PF
    CG1106-PJ
    CG1106-PK
    CG1106-PL
    Gel-PA
    Gel-PB
    Gel-PD
    Gel-PF
    Gel-PJ
    Gel-PK
    Gel-PL
    drosophila gelsolin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4235217..4241057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164321.5 → NP_730790.2  gelsolin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730790.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2C8, A9UNC4, Q07171, Q0KIE3, Q0KIE4, Q8MRF9, Q9VMZ1, Q9VMZ2
      UniProtKB/TrEMBL
      A0A0C4DHG2
      Related
      FBpp0078608
      Conserved Domains (5) summary
      cd11289
      Location:191 → 283
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:63 → 176
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:675 → 774
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:307 → 404
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:569 → 661
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. NM_206427.4 → NP_996149.3  gelsolin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996149.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2C8, A9UNC4, Q07171, Q0KIE3, Q0KIE4, Q8MRF9, Q9VMZ1, Q9VMZ2
      UniProtKB/TrEMBL
      A0A0C4DHG2
      Conserved Domains (5) summary
      cd11289
      Location:191 → 283
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:63 → 176
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:675 → 774
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:307 → 404
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:569 → 661
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    3. NM_080126.4 → NP_524865.2  gelsolin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524865.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2C8, A9UNC4, Q07171, Q0KIE3, Q0KIE4, Q8MRF9, Q9VMZ1, Q9VMZ2
      UniProtKB/TrEMBL
      A0A0C4DHG2
      Related
      FBpp0078607
      Conserved Domains (5) summary
      cd11289
      Location:191 → 283
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:63 → 176
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:675 → 774
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:307 → 404
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:569 → 661
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    4. NM_176394.3 → NP_788571.1  gelsolin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788571.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2C8, A9UNC4, Q07171, Q0KIE3, Q0KIE4, Q8MRF9, Q9VMZ1, Q9VMZ2
      UniProtKB/TrEMBL
      A0A0C4DHG2
      Related
      FBpp0078612
      Conserved Domains (5) summary
      cd11289
      Location:191 → 283
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:63 → 176
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:675 → 774
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:307 → 404
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:569 → 661
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    5. NM_001043192.3 → NP_001036657.2  gelsolin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036657.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHG6
      Conserved Domains (5) summary
      cd11289
      Location:133 → 225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 118
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:617 → 716
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:249 → 346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:511 → 603
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    6. NM_206426.4 → NP_996148.2  gelsolin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996148.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07171
      Conserved Domains (5) summary
      cd11289
      Location:179 → 271
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:51 → 164
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:663 → 762
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:295 → 392
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:557 → 649
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    7. NM_164319.4 → NP_730788.1  gelsolin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHG6
      Related
      FBpp0078610
      Conserved Domains (5) summary
      cd11289
      Location:133 → 225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 118
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:617 → 716
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:249 → 346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:511 → 603
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHG2 A0A0C4DHG2
    A0A0C4DHG6 A0A0C4DHG6
    Q07171.2 Q07171

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