mth methuselah [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mthprovided by FlyBase
Official Full Name: methuselahprovided by FlyBase
Primary source: FLYBASE:FBgn0023000
Locus tag: Dmel_CG6936
See related: AllianceGenome:FB:FBgn0023000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6936; Dmel\CG6936; Mth; MTH
Summary: Enables G protein-coupled peptide receptor activity and peptide binding activity. Involved in several processes, including determination of adult lifespan; response to paraquat; and synaptic vesicle exocytosis. Located in plasma membrane. Is expressed in several structures, including amnioproctodeal invagination; embryonic/larval dorsal pouch; embryonic/larval pharynx; epithelial furrow; and imaginal disc. Used to study alcohol-related neurodevelopmental disorder. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61C1-61C1; 3-0.5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (343378..346957, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (343378..346957, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study identifies Methuselah (Mth) as a secretin-incretin receptor subfamily member required in the insulin-producing cells for proper nutrient coupling.
Title: Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor.
Methuselah gene mutation is associated with tolerance of dichlorvos exposure in Drosophila melanogaster.
Title: Efficacy of methuselah gene mutation toward tolerance of dichlorvos exposure in Drosophila melanogaster.
mth has a statistically significant advantage in maintaining continuous flight over control flies at age 10 days, but not during middle and late life. mth flies had lower levels of locomotor activity relative to controls at ages 50 and 60 days.
Title: Improved functional abilities of the life-extended Drosophila mutant Methuselah are reversed at old age to below control levels.
While our data support a role for mth variation being under natural selection, we found no link to naturally occurring variation in lifespan and ageing in Australian populations of D. melanogaster.
Title: Complexity of the genetic basis of ageing in nature revealed by a clinal study of lifespan and methuselah, a gene for ageing, in Drosophila from eastern Australia.
Identified two additional activators of Mth signaling: Drosophila Sex Peptide (SP) and a novel peptide (Serendipitous Peptide Activator of Mth, SPAM).
Title: The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides.
allelic variation at mth contributes to observed differences in lifespan and correlated phenotypes in natural populations of Drosophila
Title: Functional significance of allelic variation at methuselah, an aging gene in Drosophila.
Mth gene delays chronological aging but also enhances sensorimotor abilities critical to survival during early and middle, but not late life.
Title: Age-dependent stability of sensorimotor functions in the life-extended Drosophila mutant methuselah.
Results support the view that methuselah expression is regulated by dorsal.
Title: Transcriptional regulation of the methuselah gene by dorsal protein in Drosophila melanogaster.
where the life span is extended, there is an offsetting effect on reproductive output, suggesting that the methuselah mutation induces trade-off effects and is not a direct, mechanistic regulator of the aging process.
Title: Temperature-dependent trade-offs between longevity and fertility in the Drosophila mutant, methuselah.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to paraquat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: methuselah

Names: CG6936-PA; CG6936-PB; CG6936-PE; methusalah; mth-PA; mth-PB; mth-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

343378..346957 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167829.3 → NP_728521.1 methuselah, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728521.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O97148

Related

FBpp0072470

Conserved Domains (2) summary

pfam06652
Location:29 → 209

Methuselah_N; Methuselah N-terminus

cl21561
Location:219 → 416

7tm_4; Olfactory receptor
NM_079147.4 → NP_523871.1 methuselah, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523871.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RJF9, O97148, Q9GN21, Q9GN78, Q9GND6, Q9GNE8, Q9GT57, Q9GT58, Q9GT59, Q9GT60, Q9W0R4

UniProtKB/TrEMBL

E1JHX3

Related

FBpp0072469

Conserved Domains (2) summary

pfam06652
Location:29 → 209

Methuselah_N; Methuselah N-terminus

cl21561
Location:219 → 416

7tm_4; Olfactory receptor
NM_001259606.2 → NP_001246535.1 methuselah, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246535.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RJF9, O97148, Q9GN21, Q9GN78, Q9GND6, Q9GNE8, Q9GT57, Q9GT58, Q9GT59, Q9GT60, Q9W0R4

UniProtKB/TrEMBL

E1JHX3

Conserved Domains (2) summary

pfam06652
Location:29 → 209

Methuselah_N; Methuselah N-terminus

cl21561
Location:219 → 416

7tm_4; Olfactory receptor