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    HemK1 HemK methyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HemK1provided by FlyBase
    Official Full Name
    HemK methyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031817
    Locus tag
    Dmel_CG9531
    See related
    AllianceGenome:FB:FBgn0031817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9531; Dmel\CG9531
    Summary
    Predicted to enable protein-(glutamine-N5) methyltransferase activity and protein-glutamine N-methyltransferase activity. Predicted to be involved in translational termination. Orthologous to human HEMK1 (HemK methyltransferase family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HemK1 in Genome Data Viewer
    Location:
    26D7-26D7; 2-20 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6466217..6467698, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6466217..6467698, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene farjavit Neighboring gene Ring finger and CHY zinc finger domain containing 1 Neighboring gene mummy Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for chitin biosynthesis in epithelial tube morphogenesis. Devine WP, et al. Proc Natl Acad Sci U S A, 2005 Nov 22. PMID 16287975, Free PMC Article
    2. Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine. Obata F, et al. Dev Cell, 2018 Mar 26. PMID 29587144
    3. Aβ42 Expressing Drosophila melanogaster Model for Alzheimer's Disease: Quantitative Proteomics Identifies Altered Protein Dynamics of Relevance to Neurodegeneration. Deolankar SC, et al. OMICS, 2022 Jan. PMID 35006003
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Functional dissection of an innate immune response by a genome-wide RNAi screen. Foley E, et al. PLoS Biol, 2004 Aug. PMID 15221030, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-(glutamine-N5) methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-glutamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    HemK methyltransferase 1
    Names
    CG9531-PA
    CG9531-PB
    HemK1-PA
    HemK1-PB
    NP_001260134.1
    NP_609031.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6466217..6467698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135187.4 → NP_609031.2  HemK methyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609031.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AN21, Q9VMD3
      Related
      FBpp0078900
      Conserved Domains (2) summary
      PRK09328
      Location:61 → 322
      PRK09328; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
      cl17173
      Location:84 → 288
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001273205.2 → NP_001260134.1  HemK methyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AN21, Q9VMD3
      Conserved Domains (2) summary
      PRK09328
      Location:61 → 322
      PRK09328; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
      cl17173
      Location:84 → 288
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R65 Q95R65
    Q9VMD3 Q9VMD3

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