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    Cyp1 Cyclophilin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32595, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cyp1provided by FlyBase
    Official Full Name
    Cyclophilin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004432
    Locus tag
    Dmel_CG9916
    See related
    AllianceGenome:FB:FBgn0004432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM09255; CG9916; Cpy1; cyp-1; Cyp-1; CyP-1; cyp1; CyP1; Dmel\CG9916
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp1 in Genome Data Viewer
    Location:
    14B9-14B12; 1-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16317673..16320370, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16211706..16214403, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene beta Hydroxy acid dehydrogenase 1 Neighboring gene uncharacterized protein Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Calpain C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Bernardi P, et al. Physiol Rev, 2015 Oct. PMID 26269524, Free PMC Article
    2. F-ATPase of Drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. von Stockum S, et al. J Biol Chem, 2015 Feb 20. PMID 25550160, Free PMC Article
    3. Cyclophilins: a new family of proteins involved in intracellular folding. Stamnes MA, et al. Trends Cell Biol, 1992 Sep. PMID 14731520
    4. Cyclophilin 1 (Cyp1) mutation ameliorates oxidative stress-induced defects in a Drosophila DJ-1 null mutant. Kim EY, et al. Biochem Biophys Res Commun, 2018 Nov 2. PMID 30297105
    5. The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins. Stamnes MA, et al. Cell, 1991 Apr 19. PMID 1707759

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    cyclophilin 1
    Names
    CG9916-PA
    Cyp1-PA
    Peptidyl-prolyl cis-trans isomerase
    cyclophilin
    cyclophilin1
    peptidylprolyl isomerase F
    NP_523366.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16317673..16320370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078642.4 → NP_523366.2  cyclophilin 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523366.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25007, Q9VXH8
      UniProtKB/TrEMBL
      A8E774
      Related
      FBpp0074017
      Conserved Domains (1) summary
      cd01926
      Location:67 → 225
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25007.2 P25007
    Q95S46 Q95S46

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