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    Adm adrenomedullin [ Mus musculus (house mouse) ]

    Gene ID: 11535, updated on 13-Jan-2025

    Summary

    Official Symbol
    Admprovided by MGI
    Official Full Name
    adrenomedullinprovided by MGI
    Primary source
    MGI:MGI:108058
    See related
    Ensembl:ENSMUSG00000030790 AllianceGenome:MGI:108058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AM
    Summary
    Predicted to enable adrenomedullin receptor binding activity. Involved in several processes, including circulatory system development; negative regulation of vascular permeability; and positive regulation of vasculogenesis. Acts upstream of or within chordate embryonic development; developmental growth; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; extraembryonic component; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 8.4), adrenal adult (RPKM 7.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Adm in Genome Data Viewer
    Location:
    7 E3; 7 57.7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110226864..110229027)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110627657..110629820)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SET binding factor 2 Neighboring gene predicted gene 10087 Neighboring gene ribosomal protein S8, pseudogene 1 pseudogene Neighboring gene predicted gene, 46027 Neighboring gene STARR-positive B cell enhancer ABC_E6586 Neighboring gene STARR-seq mESC enhancer starr_19827 Neighboring gene predicted gene 28863 Neighboring gene STARR-seq mESC enhancer starr_19828 Neighboring gene STARR-seq mESC enhancer starr_19829 Neighboring gene STARR-seq mESC enhancer starr_19831 Neighboring gene predicted gene, 21123 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adrenomedullin receptor binding  
    enables adrenomedullin receptor binding  
    enables adrenomedullin receptor binding  
    enables hormone activity  
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization  
    involved_in G protein-coupled receptor internalization  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adrenomedullin receptor signaling pathway  
    involved_in adrenomedullin receptor signaling pathway  
    involved_in adrenomedullin receptor signaling pathway  
    involved_in androgen metabolic process  
    involved_in androgen metabolic process  
    involved_in animal organ regeneration  
    involved_in antibacterial humoral response  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis PubMed 
    involved_in cAMP-mediated signaling  
    acts_upstream_of cell population proliferation PubMed 
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-positive bacterium  
    acts_upstream_of_or_within developmental growth PubMed 
    involved_in female pregnancy  
    acts_upstream_of_or_within heart development PubMed 
    involved_in heart development PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of vascular permeability PubMed 
    involved_in negative regulation of vasoconstriction  
    involved_in negative regulation of vasoconstriction  
    acts_upstream_of_or_within neural tube closure PubMed 
    involved_in neuron projection regeneration  
    involved_in neuron projection regeneration  
    involved_in odontogenesis of dentin-containing tooth  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of heart rate  
    involved_in positive regulation of heart rate  
    involved_in positive regulation of heart rate  
    involved_in positive regulation of vasculogenesis PubMed 
    involved_in receptor internalization  
    involved_in regulation of systemic arterial blood pressure  
    involved_in regulation of systemic arterial blood pressure  
    involved_in regulation of systemic arterial blood pressure  
    involved_in regulation of the force of heart contraction  
    involved_in regulation of the force of heart contraction  
    involved_in regulation of urine volume  
    involved_in regulation of urine volume  
    involved_in response to ether  
    involved_in response to glucocorticoid  
    involved_in response to hypoxia  
    involved_in response to insulin  
    involved_in response to lipopolysaccharide  
    involved_in response to lipopolysaccharide  
    involved_in response to starvation  
    acts_upstream_of_or_within spongiotrophoblast layer development PubMed 
    involved_in vascular associated smooth muscle cell development PubMed 
    involved_in vasculogenesis  
    involved_in vasculogenesis  
    Items 1 - 25 of 60
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009627.2NP_033757.1  pro-adrenomedullin precursor

      See identical proteins and their annotated locations for NP_033757.1

      Status: VALIDATED

      Source sequence(s)
      AC154911, AK144181
      Consensus CDS
      CCDS21745.1
      UniProtKB/Swiss-Prot
      P97297, P97453, Q6GTK2
      Related
      ENSMUSP00000033054.9, ENSMUST00000033054.10
      Conserved Domains (1) summary
      pfam00214
      Location:1149
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      110226864..110229027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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