Cd5 CD5 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd5provided by MGI
Official Full Name: CD5 antigenprovided by MGI
Primary source: MGI:MGI:88340
See related: Ensembl:ENSMUSG00000024669 AllianceGenome:MGI:88340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly-1; Ly-A; Ly-12; Lyt-1
Summary: Acts upstream of or within T cell costimulation and apoptotic signaling pathway. Located in external side of plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human CD5 (CD5 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 77.3), spleen adult (RPKM 17.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 7.16 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10695471..10716390, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10718107..10739026, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice.
Title: CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice.
CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity.
Title: CD5 blockade enhances ex vivo CD8(+) T cell activation and tumour cell cytotoxicity.
CD5 dynamically calibrates basal NF-kappaB signaling in T cells during thymic development and peripheral activation.
Title: CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.
Collectively, these data demonstrate that the specific expression of CD5 on dendritic cells inhibits the production of inflammatory cytokines and has a regulatory effect on their activity to stimulate T cells and induce immune responses.
Title: CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.
A novel role for BTK in regulating CD1d(hi)CD5(+) Breg differentiation.
Title: BTK signaling drives CD1d(hi)CD5(+) regulatory B-cell differentiation to promote pancreatic carcinogenesis.
Binding studies show that both soluble and membrane-bound forms of CD5 and CD6 bind to intact viable protoscoleces from E. granulosus s.l. through recognition of metaperiodate-resistant tegumental components.
Title: The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis.
The natural substrate for the cell surface sialidase was identified as clustered differentiation 5 (CD5) by PNA-blot analysis of anti-CD5 immunoprecipitate.
Title: Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5.
FasL expression in splenic CD5(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 ligation.
Title: TLR4 supports the expansion of FasL(+)CD5(+)CD1d(hi) regulatory B cells, which decreases in contact hypersensitivity.
CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals
Title: CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.
the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.
Title: CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Spontaneous (2) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

M15177 (e-PCR)
- UniSTS:160796

Cd5 (e-PCR), detects polymorphism
- UniSTS:141288

M15177 (e-PCR)
- UniSTS:124920

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-cell surface glycoprotein CD5

Names: lymphocyte antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007650.3 → NP_031676.3 T-cell surface glycoprotein CD5 precursor

See identical proteins and their annotated locations for NP_031676.3

Status: VALIDATED

Source sequence(s)

AC132247, AI528619, AK143736

Consensus CDS

CCDS29586.1

UniProtKB/Swiss-Prot

P13379

UniProtKB/TrEMBL

Q3UP78, Q91X69

Related

ENSMUSP00000025571.8, ENSMUST00000025571.9

Conserved Domains (2) summary

smart00202
Location:34 → 133

SR; Scavenger receptor Cys-rich

pfam00530
Location:168 → 268

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10695471..10716390 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526621.2 → XP_006526684.1 T-cell surface glycoprotein CD5 isoform X1

UniProtKB/TrEMBL

A0A494BB49

Related

ENSMUSP00000158313.2, ENSMUST00000238167.2

Conserved Domains (1) summary

smart00202
Location:34 → 133

SR; Scavenger receptor Cys-rich