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    Eif3b eukaryotic translation initiation factor 3, subunit B [ Mus musculus (house mouse) ]

    Gene ID: 27979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif3bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Bprovided by MGI
    Primary source
    MGI:MGI:106478
    See related
    Ensembl:ENSMUSG00000056076 AllianceGenome:MGI:106478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRT1; Eif3s9; D5Wsu45e; EIF3-ETA; EIF3-P110; EIF3-P116
    Summary
    Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system; extraembryonic component; and sensory organ. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 106.5), ovary adult (RPKM 52.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif3b in Genome Data Viewer
    Location:
    5 G2; 5 78.97 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140405060..140429113)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140419305..140443358)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 8 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene predicted gene, 30550 Neighboring gene STARR-positive B cell enhancer ABC_E1696 Neighboring gene microRNA 7038 Neighboring gene STARR-seq mESC enhancer starr_14711 Neighboring gene kinesin family member 19B Neighboring gene STARR-positive B cell enhancer ABC_E2181 Neighboring gene STARR-positive B cell enhancer ABC_E11306 Neighboring gene predicted gene, 38728 Neighboring gene STARR-positive B cell enhancer ABC_E10361 Neighboring gene carbohydrate sulfotransferase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Embryonic lethality of mutant mice deficient in the p116 gene. Koyanagi-Katsuta R, et al. J Biochem, 2002 Jun. PMID 12038979
    2. The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis. Tang X, et al. Med Sci Monit, 2018 Dec 17. PMID 30556540, Free PMC Article
    3. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Yang W, et al. Cell Chem Biol, 2023 Oct 19. PMID 37442135
    4. TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. Perez RC, et al. J Mol Histol, 2024 Feb. PMID 38165569
    5. Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. Nedelko T, et al. BMC Genomics, 2012 Aug 20. PMID 22905720, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data illustrate a novel mechanism of piR-823 in HSC activities. The combination of piR-823 and EIF3B increased TGF-beta1 expression, which activates HSCs in liver fibrosis.
      Title: The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis.
    2. results indicate that p116 plays an essential role in the early stages of mouse development[eIF3 p116]
      Title: Embryonic lethality of mutant mice deficient in the p116 gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral translational termination-reinitiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational termination-reinitiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit B
    Names
    eIF-3-eta
    eIF3 p116
    eukaryotic translation initiation factor 3 subunit 9
    eukaryotic translation initiation factor 3, subunit 9 (eta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133916.2 → NP_598677.1  eukaryotic translation initiation factor 3 subunit B

      See identical proteins and their annotated locations for NP_598677.1

      Status: PROVISIONAL

      Source sequence(s)
      AC131670
      Consensus CDS
      CCDS19819.1
      UniProtKB/Swiss-Prot
      Q8JZQ9, Q922K2
      UniProtKB/TrEMBL
      Q8CIJ3
      Related
      ENSMUSP00000098076.4, ENSMUST00000100507.8
      Conserved Domains (4) summary
      PHA03249
      Location:26 → 148
      PHA03249; DNA packaging tegument protein UL25; Provisional
      COG5354
      Location:297 → 796
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      cd12278
      Location:173 → 253
      RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
      sd00039
      Location:365 → 412
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140405060..140429113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZQ9.1 GenPept UniProtKB/Swiss-Prot:Q8JZQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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