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    Rasl11b RAS-like, family 11, member B [ Mus musculus (house mouse) ]

    Gene ID: 68939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasl11bprovided by MGI
    Official Full Name
    RAS-like, family 11, member Bprovided by MGI
    Primary source
    MGI:MGI:1916189
    See related
    Ensembl:ENSMUSG00000049907 AllianceGenome:MGI:1916189
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190017B18Rik
    Summary
    Enables transforming growth factor beta receptor binding activity. Acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Is expressed in limb mesenchyme; lung; musculoskeletal system; sensory organ; and vibrissa. Orthologous to human RASL11B (RAS like family 11 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 48.9), limb E14.5 (RPKM 38.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasl11b in Genome Data Viewer
    Location:
    5 C3.3; 5 39.43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (74355987..74360138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (74195326..74199477)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene differentiation antagonizing non-protein coding RNA Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74596657-74596859 Neighboring gene predicted gene, 32002 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74656347-74656530 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74656616-74656725 Neighboring gene Sec1 family domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13406 Neighboring gene predicted gene, 32064 Neighboring gene VISTA enhancer mm139 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74762842-74763025 Neighboring gene STARR-seq mESC enhancer starr_13407 Neighboring gene STARR-positive B cell enhancer ABC_E2746 Neighboring gene STARR-positive B cell enhancer ABC_E6339 Neighboring gene factor interacting with PAPOLA and CPSF1 Neighboring gene ligand of numb-protein X 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Piek E, et al. Biochem J, 2004 Oct 1. PMID 15239668, Free PMC Article
    2. Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Hupe M, et al. Nucleic Acids Res, 2014 Jan. PMID 24165879, Free PMC Article
    3. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
    4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103217

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-like protein family member 11B
    NP_081154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026878.1 → NP_081154.1  ras-like protein family member 11B

      See identical proteins and their annotated locations for NP_081154.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083068
      Consensus CDS
      CCDS39113.1
      UniProtKB/Swiss-Prot
      Q922H7, Q9D0S0
      Related
      ENSMUSP00000053389.7, ENSMUST00000051937.9
      Conserved Domains (2) summary
      cd04146
      Location:34 → 201
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
      smart00173
      Location:34 → 200
      RAS; Ras subfamily of RAS small GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      74355987..74360138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922H7.1 GenPept UniProtKB/Swiss-Prot:Q922H7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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