Zfand2a zinc finger, AN1-type domain 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfand2aprovided by MGI
Official Full Name: zinc finger, AN1-type domain 2Aprovided by MGI
Primary source: MGI:MGI:2140729
See related: Ensembl:ENSMUSG00000053581 AllianceGenome:MGI:2140729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Airap
Summary: Predicted to enable zinc ion binding activity. Acts upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Part of proteasome complex. Is expressed in cerebral cortex. Orthologous to human ZFAND2A (zinc finger AN1-type containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 12.9), frontal lobe adult (RPKM 11.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 78.68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (139456971..139470246, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (139471216..139484491, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
Title: An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
arsenite- inducible regulatory particle-associated protein (AIRAP) transcript to be translationally induced during arsenite stress conditions.
Title: Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation.
AIRAP adapts the cell's core protein degradation machinery to counteract proteotoxicity induced by an environmental toxin.
Title: An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU016206 (e-PCR)
- UniSTS:179302

RH124651 (e-PCR)
- UniSTS:161473

RH125749 (e-PCR)
- UniSTS:162503

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AN1-type zinc finger protein 2A

Names: arsenite inducible RNA associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.