Acp1 acid phosphatase 1, soluble [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acp1provided by MGI
Official Full Name: acid phosphatase 1, solubleprovided by MGI
Primary source: MGI:MGI:87881
See related: Ensembl:ENSMUSG00000044573 AllianceGenome:MGI:87881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acp-1; Lmptp; LMW-PTP; 4632432E04Rik
Summary: Enables acid phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytosol and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 13.0 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (30943325..30961616, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (30893326..30911619, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
Title: The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
Our data show that ablation of Lmptp inhibits pathological cardiac remodelling
Title: Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
Data indicate there was no significant change in low molecular weight protein tyrosine phosphatase (LMW-PTP) expression at 30 min or 2 h.
Title: Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP.
The expression and activity of Src and low molecular weight protein tyrosine phosphatase (LMWPTP) during osteoblast differentiation was examined and the modulation of Src kinase by LMWPTP was assessed.
Title: Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.
low M(r) phosphotyrosine protein phosphatase participation in FAK-mediated focal adhesion remodeling.
Title: Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading.
The formation of LMW-PTP/caveolin-1 complexes is accompanied by modulation of the enzyme activities, and the inhibitory effect elicited against IF1 is stronger than that against IF2
Title: Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation.
plays a role on PDGF receptor signaling and controls PDGF-r kinase activity through TYR-857 dephosphorylation
Title: Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation.
The redox-dependent enhancement of Grb2 recruitment to LMW-PTP ultimately leads to an improvement of ERK activation, likely triggering a prosurvival signal against the oxidant environment.
Title: A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI427468 (e-PCR)
- UniSTS:185929

RH124866 (e-PCR)
- UniSTS:161688

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: low molecular weight phosphotyrosine protein phosphatase

Names: LMW-PTPase; low molecular weight cytosolic acid phosphatase

NP_001103709.1

EC 3.1.3.2

EC 3.1.3.48

NP_067305.2

EC 3.1.3.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110239.1 → NP_001103709.1 low molecular weight phosphotyrosine protein phosphatase isoform 1

See identical proteins and their annotated locations for NP_001103709.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the predominant isoform (1, also known as IF2).

Source sequence(s)

AC160932, AK014603, AK152429

Consensus CDS

CCDS49045.1

UniProtKB/TrEMBL

Q561M1

Related

ENSMUSP00000073686.6, ENSMUST00000074038.7

Conserved Domains (1) summary

cd16343
Location:7 → 155

LMWPTP; Low molecular weight protein tyrosine phosphatase
NM_021330.4 → NP_067305.2 low molecular weight phosphotyrosine protein phosphatase isoform 2

See identical proteins and their annotated locations for NP_067305.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2, also known as IF1) is the same length as isoform 1 but differs at an internal region, compared to isoform 1.

Source sequence(s)

AC160932, AK082955

Consensus CDS

CCDS36427.1

UniProtKB/Swiss-Prot

O88739, O88740, Q9D358, Q9QWF5

UniProtKB/TrEMBL

Q4VAI2

Related

ENSMUSP00000106509.4, ENSMUST00000062740.15

Conserved Domains (1) summary

cd00115
Location:7 → 155

LMWPc; Low molecular weight phosphatase family;