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    LINC00668 long intergenic non-protein coding RNA 668 [ Homo sapiens (human) ]

    Gene ID: 400643, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00668provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 668provided by HGNC
    Primary source
    HGNC:HGNC:44328
    See related
    Ensembl:ENSG00000265933 AllianceGenome:HGNC:44328
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 11.7), colon (RPKM 6.5) and 4 other tissues See more
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    Genomic context

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    See LINC00668 in Genome Data Viewer
    Location:
    18p11.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (6925474..6929869, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (7086009..7090408, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (6925473..6929868, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985176 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:6605546-6606358 Neighboring gene RNA, 7SL, cytoplasmic 282, pseudogene Neighboring gene ARHGAP28 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6729485-6730448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6740450-6740950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6740951-6741451 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6751961-6752536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6752537-6753112 Neighboring gene Rho GTPase activating protein 28 Neighboring gene NANOG hESC enhancer GRCh37_chr18:6782830-6783412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:6951323-6951880 Neighboring gene uncharacterized LOC101927188 Neighboring gene RNA, U6 small nuclear 916, pseudogene Neighboring gene SCML2 pseudogene 1 Neighboring gene laminin subunit alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and 
Promotes Tumor Cell Migration and Invasion]. Yuan B, et al. Zhongguo Fei Ai Za Zhi, 2022 Apr 20. PMID 35477186, Free PMC Article
    2. LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation. Liu Z, et al. Neurochem Res, 2020 Jul. PMID 32279214
    3. LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis. Xuan W, et al. Biosci Rep, 2020 May 29. PMID 32249890, Free PMC Article
    4. Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma. Wang X, et al. Int J Oncol, 2019 Oct. PMID 31432149, Free PMC Article
    5. Expression profile analysis identifies the long non-coding RNA landscape and the potential carcinogenic functions of LINC00668 in laryngeal squamous cell carcinoma. Zhao L, et al. Gene, 2019 Mar 1. PMID 30415008

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis.
      Title: LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis.
    2. [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and Promotes Tumor Cell Migration and Invasion].
      Title: [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and 
Promotes Tumor Cell Migration and Invasion].
    3. LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation.
      Title: LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation.
    4. LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis.
      Title: LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis.
    5. Study identified that lncRNA LINC00668 is differentially expressed and upregulated in hepatocellular carcinoma (HCC) tissue. It functions as an oncogene and its high expression leads to poor prognosis for HCC.
      Title: Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma.
    6. STAT3-induced LINC00668 contributed to non-small cell lung cancer progression through upregulating KLF7 expression by sponging miR-193a.
      Title: STAT3-induced long noncoding RNA LINC00668 promotes migration and invasion of non-small cell lung cancer via the miR-193a/KLF7 axis.
    7. lncRNA LINC00668 acted as an oncogenic role in CRC cells by sponging miR-188-5p and upregulating USP47
      Title: LINC00668 promotes tumorigenesis and progression through sponging miR-188-5p and regulating USP47 in colorectal cancer.
    8. High LINC00668 expression is associated with laryngeal squamous cell carcinoma.
      Title: Expression profile analysis identifies the long non-coding RNA landscape and the potential carcinogenic functions of LINC00668 in laryngeal squamous cell carcinoma.
    9. High LINC00668 expression is associated with gastric cancer.
      Title: E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Clone Names

    • FLJ38028

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_034100.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP005210
      Related
      ENST00000581571.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      6925474..6929869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      7086009..7090408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001103383.1: Suppressed sequence

      Description
      NM_001103383.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.