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    FKBP11 FKBP prolyl isomerase 11 [ Homo sapiens (human) ]

    Gene ID: 51303, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FKBP11provided by HGNC
    Official Full Name
    FKBP prolyl isomerase 11provided by HGNC
    Primary source
    HGNC:HGNC:18624
    See related
    Ensembl:ENSG00000134285 MIM:610571; AllianceGenome:HGNC:18624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKBP19
    Summary
    FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in pancreas (RPKM 27.0), appendix (RPKM 17.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FKBP11 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48921963..48939034, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48884157..48887686, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49315746..49319275, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4414 Neighboring gene ribosomal protein L32 pseudogene 27 Neighboring gene coiled-coil domain containing 65 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4415 Neighboring gene ARF GTPase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49338542-49339042 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49340991-49341204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49341223-49341815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49349467-49350462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6297 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49353706-49353915 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49358123-49358716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49360112-49360664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49361393-49362276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4416 Neighboring gene Sharpr-MPRA regulatory region 4091 Neighboring gene Wnt family member 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human FK506-binding proteins: characterization of human FKBP19. Rulten SL, et al. Mamm Genome, 2006 Apr. PMID 16596453
    2. FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma. Thokerunga E, et al. Cancer Biomark, 2023. PMID 37248890
    3. FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma. Zeng D, et al. Aging (Albany NY), 2023 Apr 1. PMID 37014329, Free PMC Article
    4. Identification of FKBP11 as a biomarker for hepatocellular carcinoma. Lin IY, et al. Anticancer Res, 2013 Jun. PMID 23749938
    5. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Preisendörfer S, et al. Cells, 2022 Apr 14. PMID 35456020, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma.
      Title: FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma.
    2. FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma.
      Title: FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma.
    3. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.
      Title: FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.
    4. FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma.
      Title: FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma.
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate.
      Title: Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.
    6. results suggest a progressively elevated expression of FKBP11 during the development of hepatocellular carcinoma
      Title: Identification of FKBP11 as a biomarker for hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC54182

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP11
    Names
    19 kDa FK506-binding protein
    19 kDa FKBP
    FK506 binding protein 11, 19 kDa
    FK506-binding protein 11
    FKBP-11
    FKBP-19
    PPIase FKBP11
    rotamase
    NP_001137253.1
    NP_001137254.1
    NP_057678.1
    XP_047284895.1
    XP_047284896.1
    XP_054228172.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143781.2 → NP_001137253.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 2

      See identical proteins and their annotated locations for NP_001137253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC073610, AY358998, BE857354
      Consensus CDS
      CCDS44870.1
      UniProtKB/TrEMBL
      E9PAR0
      Related
      ENSP00000412403.2, ENST00000444214.6
      Conserved Domains (1) summary
      COG0545
      Location:1 → 40
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001143782.2 → NP_001137254.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001137254.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK301455
      Consensus CDS
      CCDS44871.1
      UniProtKB/Swiss-Prot
      Q9NYL4
      Related
      ENSP00000396874.2, ENST00000453172.2
      Conserved Domains (1) summary
      pfam00254
      Location:50 → 128
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    3. NM_016594.3 → NP_057678.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AY358998
      Consensus CDS
      CCDS8773.1
      UniProtKB/Swiss-Prot
      B4DWB7, Q9NYL4
      Related
      ENSP00000449751.1, ENST00000550765.6
      Conserved Domains (1) summary
      pfam00254
      Location:50 → 141
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48921963..48939034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428939.1 → XP_047284895.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X1

    2. XM_047428940.1 → XP_047284896.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48884157..48887686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372197.1 → XP_054228172.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYL4.1 GenPept UniProtKB/Swiss-Prot:Q9NYL4

    Gene LinkOut

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