CEBPB CCAAT enhancer binding protein beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: CEBPBprovided by HGNC
Official Full Name: CCAAT enhancer binding protein betaprovided by HGNC
Primary source: HGNC:HGNC:1834
See related: Ensembl:ENSG00000172216 MIM:189965; AllianceGenome:HGNC:1834
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCF5; IL6DBP; NF-IL6; C/EBP-beta
Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Orthologs: mouse all
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Genomic context

Location:: 20q13.13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (50190583..50192690)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (51960086..51962193)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (48807120..48809227)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPbeta.
Title: Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ.
Dysregulation of TNF-induced protein 3 and CCAAT/enhancer-binding protein beta in alveolar macrophages: Implications for systemic sclerosis-associated interstitial lung disease.
Title: Dysregulation of TNF-induced protein 3 and CCAAT/enhancer-binding protein β in alveolar macrophages: Implications for systemic sclerosis-associated interstitial lung disease.
rs822336 binding to C/EBPbeta and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.
Title: rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.
MiR-155-5p improves the insulin sensitivity of trophoblasts by targeting CEBPB in gestational diabetes mellitus.
Title: MiR-155-5p improves the insulin sensitivity of trophoblasts by targeting CEBPB in gestational diabetes mellitus.
[C/EBPbeta mediates expressions of downstream inflammatory factors of the tumor necrosis factor-alpha signaling pathway in renal tubular epithelial cells with NPHP1 knockdown].
Title: [C/EBPβ mediates expressions of downstream inflammatory factors of the tumor necrosis factor-α signaling pathway in renal tubular epithelial cells with NPHP1 knockdown].
Transcriptional factor CCAAT enhancer binding protein beta inhibits epithelial-mesenchymal transition in cervical cancer via regulating attractin-like 1.
Title: Transcriptional factor CCAAT enhancer binding protein beta inhibits epithelial-mesenchymal transition in cervical cancer via regulating attractin-like 1.
Assessing the double-edged of extracellular signal-regulated kinase/CCAAT-enhancer-binding protein beta signaling pathway in arsenic-induced skin damage and its potential foodborne interventions.
Title: Assessing the double-edged of extracellular signal-regulated kinase/CCAAT-enhancer-binding protein beta signaling pathway in arsenic-induced skin damage and its potential foodborne interventions.
Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
Title: Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
CRISPR screen identifies CEBPB as contributor to dyskeratosis congenita fibroblast senescence via augmented inflammatory gene response.
Title: CRISPR screen identifies CEBPB as contributor to dyskeratosis congenita fibroblast senescence via augmented inflammatory gene response.
Inhibition of abnormal C/EBPbeta/alpha-Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease-like pathology.
Title: Inhibition of abnormal C/EBPβ/α-Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease-like pathology.

Submit: New GeneRIF Correction See all GeneRIFs (351)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates C/EBPbeta expression in human mesenchymal stem cells	PubMed
Tat	tat	The gene expression of CCAAT/enhancer binding protein beta is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells	PubMed
	tat	The synergistic interaction between C/EBPbeta-2 and Tat with the subtype C LTR is observed in U-937 cells	PubMed
	tat	Tat-C/EBPbeta association is mediated through cdk9, which phosphorylates C/EBPbeta	PubMed
	tat	Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production	PubMed
	tat	Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes	PubMed
	tat	Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes	PubMed
	tat	HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47)	PubMed
	tat	HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity	PubMed
	tat	HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia	PubMed
Vif	vif	NF-IL6 facilitates the reverse transcription of HIV-1 by binding to and inhibiting the antiviral cytidine deaminase APOBEC3G. A mutation in NF-IL6 at Ser-288 weakens its binding to APOBEC3G and strongly inhibits HIV-1 replication	PubMed
Vpr	vpr	HIV-1 Vpr-induced retrotransposition of long interspersed element-1 depends on an AhR-MAPK/p38-C/EBP-beta cascade via the LQQLL motif of Vpr	PubMed
	vpr	HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88	PubMed
	vpr	Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6	PubMed
	vpr	HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17476 (e-PCR)
- UniSTS:79118

D20S728 (e-PCR)
- UniSTS:3208

STS-H26183 (e-PCR)
- UniSTS:32399

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T-helper 1 cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in acute-phase response	TAS Traceable Author Statement more info	PubMed
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in granuloma formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in integrated stress response signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	TAS Traceable Author Statement more info	PubMed
involved_in liver regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of biomineral tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of biomineral tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in regulation of odontoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of C/EBP complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CHOP-C/EBP complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CHOP-C/EBP complex	NAS Non-traceable Author Statement more info	PubMed
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in condensed chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: CCAAT/enhancer-binding protein beta

Names: CCAAT/enhancer binding protein (C/EBP), beta; interleukin 6-dependent DNA-binding protein; nuclear factor NF-IL6; nuclear factor of interleukin 6; transcription factor 5; transcription factor C/EBP beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029019.1 RefSeqGene

Range

4992..6830

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001285878.1 → NP_001272807.1 CCAAT/enhancer-binding protein beta isoform b

Status: REVIEWED

Source sequence(s)

AW025406, BC007538, DB457615

UniProtKB/Swiss-Prot

P17676

Conserved Domains (1) summary

cd14712
Location:241 → 311

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
NM_001285879.1 → NP_001272808.1 CCAAT/enhancer-binding protein beta isoform c

Status: REVIEWED

Source sequence(s)

AW025406, BC007538, DB457615

UniProtKB/TrEMBL

Q9BSC0

Conserved Domains (1) summary

cd14712
Location:66 → 136

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
NM_005194.4 → NP_005185.2 CCAAT/enhancer-binding protein beta isoform a

See identical proteins and their annotated locations for NP_005185.2

Status: REVIEWED

Source sequence(s)

BC007538, DB457615

Consensus CDS

CCDS13429.1

UniProtKB/Swiss-Prot

A8K671, P17676, Q96IH2, Q9H4Z5

Related

ENSP00000305422.3, ENST00000303004.5

Conserved Domains (1) summary

cd14712
Location:264 → 334

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain