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    Slc38a7 solute carrier family 38, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 234595, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc38a7provided by MGI
    Official Full Name
    solute carrier family 38, member 7provided by MGI
    Primary source
    MGI:MGI:2679005
    See related
    Ensembl:ENSMUSG00000036534 AllianceGenome:MGI:2679005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D430050E18
    Summary
    Enables L-glutamine:sodium symporter activity. Involved in glutamine transport and sodium ion transport. Located in axon and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human SLC38A7 (solute carrier family 38 member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 17.0), ovary adult (RPKM 10.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc38a7 in Genome Data Viewer
    Location:
    8 D1; 8 47.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96562548..96580205, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95835920..95853577, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Sin3-associated polypeptide 18B Neighboring gene STARR-seq mESC enhancer starr_22403 Neighboring gene predicted gene, 31805 Neighboring gene STARR-positive B cell enhancer ABC_E2872 Neighboring gene glutamatic-oxaloacetic transaminase 2, mitochondrial Neighboring gene predicted gene, 51586

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Verdon Q, et al. Proc Natl Acad Sci U S A, 2017 May 2. PMID 28416685, Free PMC Article
    2. Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. Hägglund MG, et al. J Biol Chem, 2011 Jun 10. PMID 21511949, Free PMC Article
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Clone Names

    • MGC25764

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-asparagine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-asparagine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-asparagine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-glutamine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid transporter 7
    Names
    amino acid transporter
    putative sodium-coupled neutral amino acid transporter 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426703.1 → NP_001413632.1  sodium-coupled neutral amino acid transporter 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127300
      UniProtKB/Swiss-Prot
      Q3TBN9, Q8BWH0, Q8K2B1
      Related
      ENSMUSP00000148659.2, ENSMUST00000212270.2

    2. NM_001426704.1 → NP_001413633.1  sodium-coupled neutral amino acid transporter 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127300
      UniProtKB/Swiss-Prot
      Q3TBN9, Q8BWH0, Q8K2B1

    3. NM_001426705.1 → NP_001413634.1  sodium-coupled neutral amino acid transporter 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127300

    4. NM_001426706.1 → NP_001413635.1  sodium-coupled neutral amino acid transporter 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127300

    5. NM_001426707.1 → NP_001413636.1  sodium-coupled neutral amino acid transporter 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127300

    6. NM_001426708.1 → NP_001413637.1  sodium-coupled neutral amino acid transporter 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127300

    7. NM_172758.5 → NP_766346.1  sodium-coupled neutral amino acid transporter 7 isoform 1

      See identical proteins and their annotated locations for NP_766346.1

      Status: VALIDATED

      Source sequence(s)
      AC127300
      Consensus CDS
      CCDS22567.1
      UniProtKB/Swiss-Prot
      Q3TBN9, Q8BWH0, Q8K2B1
      UniProtKB/TrEMBL
      A0A1D5RLX9
      Related
      ENSMUSP00000037023.4, ENSMUST00000040481.4
      Conserved Domains (1) summary
      cl00456
      Location:49 → 458
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96562548..96580205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530878.1 → XP_006530941.1  sodium-coupled neutral amino acid transporter 7 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLX9
      Related
      ENSMUSP00000148545.2, ENSMUST00000212628.2
      Conserved Domains (1) summary
      cl00456
      Location:49 → 339
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWH0.1 GenPept UniProtKB/Swiss-Prot:Q8BWH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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