Tbc1d10c TBC1 domain family, member 10c [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbc1d10cprovided by MGI
Official Full Name: TBC1 domain family, member 10cprovided by MGI
Primary source: MGI:MGI:1922072
See related: Ensembl:ENSMUSG00000040247 AllianceGenome:MGI:1922072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810062O14Rik
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of B cell activation; negative regulation of ERK1 and ERK2 cascade; and negative regulation of calcineurin-NFAT signaling cascade. Predicted to be located in filopodium membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in thymus primordium. Orthologous to human TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 226.6), spleen adult (RPKM 150.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.88 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4234356..4241194, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4184357..4191195, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
Title: Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response.
Title: Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response.
TBC1D10C is a cytoskeletal functional linker that modulates cell spreading and phagocytosis in macrophages.
Title: TBC1D10C is a cytoskeletal functional linker that modulates cell spreading and phagocytosis in macrophages.
Carabin functions as an endogenous inhibitor of calcineurin, Ras and CamKII kinase which resulted in protection against cardiac hypertrophy.
Title: Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses
Title: Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488200

AI428527 (e-PCR)
- UniSTS:181175

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of B cell activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carabin

Names: EBP50-PDZ interactor of 64 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178650.3 → NP_848765.2 carabin

Status: VALIDATED

Source sequence(s)

AA217314, AK040487, BQ829173

Consensus CDS

CCDS37885.1

UniProtKB/Swiss-Prot

Q3V3L7, Q6KAN0, Q8C2R6, Q8C6F7, Q8C9V1

Related

ENSMUSP00000158437.2, ENSMUST00000235450.2

Conserved Domains (1) summary

smart00164
Location:87 → 292

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

4234356..4241194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161397.1 → XP_036017290.1 carabin isoform X3

Conserved Domains (1) summary

pfam00566
Location:2 → 106

RabGAP-TBC; Rab-GTPase-TBC domain
XM_006531628.3 → XP_006531691.1 carabin isoform X2

Conserved Domains (1) summary

smart00164
Location:87 → 278

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_036161396.1 → XP_036017289.1 carabin isoform X1

UniProtKB/Swiss-Prot

Q3V3L7, Q6KAN0, Q8C2R6, Q8C6F7, Q8C9V1

Conserved Domains (1) summary

smart00164
Location:87 → 292

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_011248598.3 → XP_011246900.1 carabin isoform X3

Conserved Domains (1) summary

pfam00566
Location:2 → 106

RabGAP-TBC; Rab-GTPase-TBC domain
XM_006531626.3 → XP_006531689.1 carabin isoform X1

UniProtKB/Swiss-Prot

Q3V3L7, Q6KAN0, Q8C2R6, Q8C6F7, Q8C9V1

Conserved Domains (1) summary

smart00164
Location:87 → 292

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs