Csnk2a1 casein kinase 2, alpha 1 polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csnk2a1provided by MGI
Official Full Name: casein kinase 2, alpha 1 polypeptideprovided by MGI
Primary source: MGI:MGI:88543
See related: Ensembl:ENSMUSG00000074698 AllianceGenome:MGI:88543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CK2; CK II alpha; Csnk2a1-rs4
Summary: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 27.4), whole brain E14.5 (RPKM 26.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.83 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152068468..152123772)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152226535..152281856)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.
Title: CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.
A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2alpha Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
Title: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
Protein Kinase CK2 Regulates B Cell Development and Differentiation.
Title: Protein Kinase CK2 Regulates B Cell Development and Differentiation.
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Title: Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Phosphorylation of Syntaxin-1a by casein kinase 2alpha regulates pre-synaptic vesicle exocytosis from the reserve pool.
Title: Phosphorylation of Syntaxin-1a by casein kinase 2α regulates pre-synaptic vesicle exocytosis from the reserve pool.
A N-terminally deleted form of the CK2alpha' catalytic subunit is sufficient to support cell viability.
Title: A N-terminally deleted form of the CK2α' catalytic subunit is sufficient to support cell viability.
Down-regulation of CK2alpha correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes.
Title: Down-regulation of CK2α correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes.
beta-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
Title: β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Title: Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Results find that CK2alpha subunit has no role in GN11 neuronal cell adhesion or migration.
Title: Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U51866 (e-PCR)
- UniSTS:125766

Csnk2a1-rs4 (e-PCR), detects polymorphism
- UniSTS:141420

16.MMHAP54FLF1.seq (e-PCR)
- UniSTS:123309

Csnk2a1 (e-PCR), detects polymorphism
- UniSTS:527299

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of aggrephagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromosome separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in PML body	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	ISO Inferred from Sequence Orthology more info
part_of protein kinase CK2 complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: casein kinase II subunit alpha

Names: casein kinase II, alpha 1 polypeptide; casein kinase II, alpha 1 related sequence 4

NP_001403894.1

EC 2.7.11.1

NP_001403895.1

EC 2.7.11.1

NP_001403896.1

EC 2.7.11.1

NP_001403897.1

EC 2.7.11.1

NP_001403898.1

EC 2.7.11.1

NP_001403899.1

EC 2.7.11.1

NP_001403900.1

EC 2.7.11.1

NP_001403901.1

EC 2.7.11.1

NP_001403902.1

EC 2.7.11.1

NP_001403903.1

EC 2.7.11.1

NP_031814.2

EC 2.7.11.1

XP_011237574.1

EC 2.7.11.1

XP_030102934.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416965.1 → NP_001403894.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416966.1 → NP_001403895.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416967.1 → NP_001403896.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416968.1 → NP_001403897.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416969.1 → NP_001403898.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416970.1 → NP_001403899.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416971.1 → NP_001403900.1 casein kinase II subunit alpha isoform 1

Status: VALIDATED

Source sequence(s)

AL831735

UniProtKB/Swiss-Prot

Q60737, Q8R0X4
NM_001416972.1 → NP_001403901.1 casein kinase II subunit alpha isoform 2

Status: VALIDATED

Source sequence(s)

AL831735
NM_001416973.1 → NP_001403902.1 casein kinase II subunit alpha isoform 3

Status: VALIDATED

Source sequence(s)

AL831735
NM_001416974.1 → NP_001403903.1 casein kinase II subunit alpha isoform 4

Status: VALIDATED

Source sequence(s)

AL831735
NM_007788.4 → NP_031814.2 casein kinase II subunit alpha isoform 1

See identical proteins and their annotated locations for NP_031814.2

Status: VALIDATED

Source sequence(s)

AL831735

Consensus CDS

CCDS16879.1

UniProtKB/Swiss-Prot

Q60737, Q8R0X4

UniProtKB/TrEMBL

Q61177

Related

ENSMUSP00000096829.4, ENSMUST00000099224.10

Conserved Domains (1) summary

cd14132
Location:20 → 325

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

152068468..152123772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247074.2 → XP_030102934.1 casein kinase II subunit alpha isoform X1

UniProtKB/Swiss-Prot

Q60737, Q8R0X4

UniProtKB/TrEMBL

Q61177

Conserved Domains (1) summary

cd14132
Location:20 → 325

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_011239272.4 → XP_011237574.1 casein kinase II subunit alpha isoform X1

See identical proteins and their annotated locations for XP_011237574.1

UniProtKB/Swiss-Prot

Q60737, Q8R0X4

UniProtKB/TrEMBL

Q61177

Conserved Domains (1) summary

cd14132
Location:20 → 325

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2