Lrrc15 leucine rich repeat containing 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc15provided by MGI
Official Full Name: leucine rich repeat containing 15provided by MGI
Primary source: MGI:MGI:1921738
See related: Ensembl:ENSMUSG00000052316 AllianceGenome:MGI:1921738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LIB; 5430427N11Rik
Summary: Predicted to enable several functions, including fibronectin binding activity; laminin binding activity; and protein sequestering activity. Predicted to be involved in several processes, including negative regulation of protein localization to plasma membrane; negative regulation of viral entry into host cell; and receptor-mediated virion attachment to host cell. Predicted to be located in cell surface and plasma membrane. Predicted to be active in apical plasma membrane; extracellular matrix; and extracellular space. Predicted to colocalize with collagen-containing extracellular matrix. Is expressed in several structures, including gonad; incisor; skin; submandibular gland; and trunk. Orthologous to human LRRC15 (leucine rich repeat containing 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 6.0), mammary gland adult (RPKM 2.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 21.23 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (30088120..30102072, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (30269302..30283254, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis.
Title: Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis.
Effect of LRRC15 on autophagy in A549 cells.
Title: Effect of LRRC15 on autophagy in A549 cells.
LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
Title: LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
Title: Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
LRRC15 is an essential regulator for osteogenesis of mesenchymal stem cells through modulating p65 cytoplasmic/nuclear translocation.
Title: LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated virion attachment to host cell	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated virion attachment to host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
colocalizes_with collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028973.2 → NP_083249.1 leucine-rich repeat-containing protein 15 precursor

See identical proteins and their annotated locations for NP_083249.1

Status: VALIDATED

Source sequence(s)

AK017350, BC050245, BX522800

Consensus CDS

CCDS28099.1

UniProtKB/Swiss-Prot

Q80X72

Related

ENSMUSP00000066777.8, ENSMUST00000064606.8

Conserved Domains (3) summary

smart00082
Location:423 → 462

LRRCT; Leucine rich repeat C-terminal domain

PLN00113
Location:82 → 401

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:127 → 150

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

30088120..30102072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160172.1 → XP_036016065.1 leucine-rich repeat-containing protein 15 isoform X1

UniProtKB/Swiss-Prot

Q80X72

Conserved Domains (3) summary

smart00082
Location:423 → 462

LRRCT; Leucine rich repeat C-terminal domain

PLN00113
Location:82 → 401

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:127 → 150

LRR_RI; leucine-rich repeat [structural motif]