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    Cd300lg CD300 molecule like family member G [ Mus musculus (house mouse) ]

    Gene ID: 52685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd300lgprovided by MGI
    Official Full Name
    CD300 molecule like family member Gprovided by MGI
    Primary source
    MGI:MGI:1289168
    See related
    Ensembl:ENSMUSG00000017309 AllianceGenome:MGI:1289168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clm9; D11Ertd736e; 2310016B05Rik
    Summary
    Enables IgM binding activity. Acts upstream of or within immunoglobulin transcytosis in epithelial cells. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human CD300LG (CD300 molecule like family member g). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 49.1), mammary gland adult (RPKM 34.6) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd300lg in Genome Data Viewer
    Location:
    11 D; 11 65.48 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101932337..101946443)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102041511..102055617)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CFAP97 domain containing 1 Neighboring gene membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) Neighboring gene predicted gene, 39393 Neighboring gene membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) Neighboring gene pancreatic polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis. Lee-Ødegård S, et al. Elife, 2024 Aug 27. PMID 39190027, Free PMC Article
    2. Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. Umemoto E, et al. PLoS One, 2013. PMID 24376728, Free PMC Article
    3. Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro. Jin S, et al. FEBS Lett, 2008 Sep 3. PMID 18675811
    4. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. Umemoto E, et al. J Exp Med, 2006 Jun 12. PMID 16754720, Free PMC Article
    5. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Takatsu H, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16876123

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nepmucin/CD300LG expression in microvascular endothelial cells
      Title: Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions.
    2. These results suggest that endothelial nepmucin promotes lymphocyte transendothelial migration using multiple adhesion pathways.
      Title: Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro.
    3. nepmucin may serve as a dual-functioning in peripheral node addressin in endothial venules mediating both lymphocyte rolling and binding via different functional domains.
      Title: Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgM binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immunoglobulin transcytosis in epithelial cells IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CMRF35-like molecule 9
    Names
    CD300 antigen like family member G
    CLM-9
    CMRF-35-like molecule-9
    nepmucin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160711.2 → NP_001154183.1  CMRF35-like molecule 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001154183.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL591145
      Consensus CDS
      CCDS48939.1
      UniProtKB/Swiss-Prot
      Q1ERP8
      Related
      ENSMUSP00000102782.3, ENSMUST00000107164.3
      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 123
      IG_like; Immunoglobulin like

    2. NM_001160712.2 → NP_001154184.1  CMRF35-like molecule 9 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001154184.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL591145
      UniProtKB/Swiss-Prot
      A2A503, Q1ERP8, Q1ERP9, Q1ERQ0, Q3UU12, Q6SJP9, Q9D7B8
      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 123
      IG_like; Immunoglobulin like

    3. NM_001160713.2 → NP_001154185.1  CMRF35-like molecule 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001154185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL591145
      Consensus CDS
      CCDS48940.1
      UniProtKB/Swiss-Prot
      Q1ERP8
      Related
      ENSMUSP00000102781.3, ENSMUST00000107163.9
      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 123
      IG_like; Immunoglobulin like

    4. NM_027987.4 → NP_082263.2  CMRF35-like molecule 9 isoform 4 precursor

      See identical proteins and their annotated locations for NP_082263.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and a segment in the CDS, as compared to variant 1. The reading frame is not affected and the resulting isoform (4) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL591145
      Consensus CDS
      CCDS25484.1
      UniProtKB/Swiss-Prot
      Q1ERP8
      Related
      ENSMUSP00000017453.6, ENSMUST00000017453.12
      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 123
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101932337..101946443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533713.1 → XP_006533776.1  CMRF35-like molecule 9 isoform X1

      Conserved Domains (2) summary
      cd05716
      Location:24 → 121
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
      PHA03247
      Location:131 → 285
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1ERP8.1 GenPept UniProtKB/Swiss-Prot:Q1ERP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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