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    Tmem168 transmembrane protein 168 [ Mus musculus (house mouse) ]

    Gene ID: 101118, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem168provided by MGI
    Official Full Name
    transmembrane protein 168provided by MGI
    Primary source
    MGI:MGI:1921794
    See related
    Ensembl:ENSMUSG00000029569 AllianceGenome:MGI:1921794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730526F17Rik; 8430437G11Rik
    Summary
    Predicted to enable sodium channel regulator activity. Acts upstream of or within regulation of ubiquitin-dependent protein catabolic process and regulation of voltage-gated sodium channel activity. Located in nuclear membrane. Is expressed in cerebral cortex ventricular layer and heart ventricle. Orthologous to human TMEM168 (transmembrane protein 168). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.0), bladder adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem168 in Genome Data Viewer
    Location:
    6 A1; 6 5.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13580688..13608097, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13580689..13608098, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15194 Neighboring gene predicted gene, 25737 Neighboring gene STARR-seq mESC enhancer starr_15196 Neighboring gene STARR-positive B cell enhancer ABC_E10370 Neighboring gene STARR-seq mESC enhancer starr_15197 Neighboring gene base methyltransferase of 25S rRNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E2186 Neighboring gene predicted gene, 53312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of transmembrane protein 168 mutation in familial Brugada syndrome. Shimizu A, et al. FASEB J, 2020 May. PMID 32175648
    2. Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics. Nguyen LKC, et al. J Biochem, 2021 Dec 28. PMID 34086898
    3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through alphaB-crystallin intracellular dynamics.
      Title: Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of voltage-gated sodium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 168

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028990.5 → NP_083266.1  transmembrane protein 168

      See identical proteins and their annotated locations for NP_083266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AC139884, AK051532
      Consensus CDS
      CCDS19915.1
      UniProtKB/Swiss-Prot
      Q3TDA5, Q91VX9
      Related
      ENSMUSP00000031554.3, ENSMUST00000031554.9

    RNA

    1. NR_155435.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC139884
      Related
      ENSMUST00000149123.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      13580688..13608097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504953.5 → XP_006505016.1  transmembrane protein 168 isoform X1

      See identical proteins and their annotated locations for XP_006505016.1

      UniProtKB/Swiss-Prot
      Q3TDA5, Q91VX9

    2. XM_006504952.5 → XP_006505015.1  transmembrane protein 168 isoform X1

      See identical proteins and their annotated locations for XP_006505015.1

      UniProtKB/Swiss-Prot
      Q3TDA5, Q91VX9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001347059.1: Suppressed sequence

      Description
      NM_001347059.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VX9.1 GenPept UniProtKB/Swiss-Prot:Q91VX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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