Pdia4 protein disulfide isomerase associated 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdia4provided by MGI
Official Full Name: protein disulfide isomerase associated 4provided by MGI
Primary source: MGI:MGI:104864
See related: Ensembl:ENSMUSG00000025823 AllianceGenome:MGI:104864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cai; Erp72; ERp-72
Summary: Enables integrin binding activity and protein disulfide isomerase activity. Acts upstream of or within blood coagulation, fibrin clot formation and platelet aggregation. Located in cell surface and endoplasmic reticulum. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo; heart; medulla oblongata basal plate; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 75.3), genital fat pad adult (RPKM 46.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 22.94 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (47773075..47790446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (47796141..47813512, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.
Title: Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.
PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue.
Title: PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue.
Pdia4 regulates beta-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
Title: Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
activated by IL11 in placenta
Title: Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice.
PDIA4 as a negative regulator of cancer cell apoptosis.
Title: Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway.
ERp72 functions separately from protein disulfide isomerase and ERp57 in supporting platelet aggregation. Defective aggregation of ERp72-null platelets was recovered by ERp72, but not other thiol isomerases.
Title: The disulfide isomerase ERp72 supports arterial thrombosis in mice.
A network of endoplasmic reticulum ERp57, ERp72, and ERp29 facilitate polyomavirus infection.
Title: A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection.
There were increased numbers of ERp72-immunoreactive cells in the dorsal and lateral cortex during sleep deprivation.
Title: Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep.
These results suggest that domains 1 and 2 of ERp72 contribute to catalytic efficacy, and domain 3 to binding affinity.
Title: Functional characterization of 3 thioredoxin homology domains of ERp72.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein disulfide isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein disulfide isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
part_of endoplasmic reticulum chaperone complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein disulfide-isomerase A4

Names: ER protein 72; calcium binding protein, intestinal; endoplasmic reticulum protein 72; endoplasmic reticulum resident protein 72

NP_001355685.1

EC 5.3.4.1

NP_033917.2

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368756.1 → NP_001355685.1 protein disulfide-isomerase A4 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC166252

UniProtKB/Swiss-Prot

P08003, P15841, Q3TT79, Q3UJW0, Q6NXW4, Q8BMT8

Conserved Domains (2) summary

TIGR01126
Location:63 → 164

pdi_dom; protein disulfide-isomerase domain

TIGR01130
Location:173 → 691

ER_PDI_fam; protein disulfide isomerase, eukaryotic
NM_009787.2 → NP_033917.2 protein disulfide-isomerase A4 isoform 2 precursor

See identical proteins and their annotated locations for NP_033917.2

Status: VALIDATED

Source sequence(s)

AK161534, BC066857, CF165880

Consensus CDS

CCDS20097.1

UniProtKB/Swiss-Prot

P08003, P15841, Q3TT79, Q3UJW0, Q6NXW4, Q8BMT8

UniProtKB/TrEMBL

A0A0R4J0Z1

Related

ENSMUSP00000076521.8, ENSMUST00000077290.9

Conserved Domains (5) summary

cd02995
Location:522 → 627

PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

cd03068
Location:282 → 388

PDI_b_ERp72; PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b; ERp72 exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting as ...

cd03073
Location:393 → 502

PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...

TIGR01126
Location:178 → 279

pdi_dom; protein disulfide-isomerase domain

TIGR01130
Location:173 → 633

ER_PDI_fam; protein disulfide isomerase, eukaryotic