Wnt7a wingless-type MMTV integration site family, member 7A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt7aprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 7Aprovided by MGI
Primary source: MGI:MGI:98961
See related: Ensembl:ENSMUSG00000030093 AllianceGenome:MGI:98961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: px; tw; Wnt-7a
Summary: Enables frizzled binding activity. Involved in several processes, including dendritic spine morphogenesis; modulation of chemical synaptic transmission; and reproductive structure development. Acts upstream of or within several processes, including blood vessel morphogenesis; central nervous system development; and embryonic limb morphogenesis. Located in cell surface and extracellular matrix. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; reproductive system; and sensory organ. Used to study Fuhrmann syndrome. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 11.5), CNS E18 (RPKM 6.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 40.45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (91340963..91388335, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (91363981..91411353, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/beta-catenin signaling.
Title: Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
WNT7A suppresses adipogenesis of skeletal muscle mesenchymal stem cells and fatty infiltration through the alternative Wnt-Rho-YAP/TAZ signaling axis.
Title: WNT7A suppresses adipogenesis of skeletal muscle mesenchymal stem cells and fatty infiltration through the alternative Wnt-Rho-YAP/TAZ signaling axis.
Basal Cell-derived WNT7A Promotes Fibrogenesis at the Fibrotic Niche in Idiopathic Pulmonary Fibrosis.
Title: Basal Cell-derived WNT7A Promotes Fibrogenesis at the Fibrotic Niche in Idiopathic Pulmonary Fibrosis.
Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer.
Title: Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer.
Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p/wingless-type MMTV integration site family member 7A axis.
Title: Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p/wingless-type MMTV integration site family member 7A axis.
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
Title: The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
Mouse embryos carrying Reck(P256A,W261A) have severe defects in forebrain angiogenesis, providing the strongest evidence to date that Reck promotes central nervous system angiogenesis by specifically stimulating Wnt7a and Wnt7b signaling.
Title: Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.
Study showed that Wnt7a in the medial insular cortex was significantly increased after 28days of morphine withdrawal, and specific down-regulation of Wnt7a alleviated the anxiety-like behavior.
Title: Wnt7a in Mouse Insular Cortex Contributes to Anxiety-like Behavior During Protracted Abstinence from Morphine.
experiments define the extent of CNS region-specific cooperation for several components of the Norrin and Wnt7a/Wnt7b systems, and they reveal substantial regional heterogeneity in the extent to which partially redundant ligands, receptors, and coactivators maintain the blood-brain barrier and blood-retina barrier
Title: Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.
Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch activation.
Title: Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (3)
Spontaneous (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt7a (e-PCR), detects polymorphism
- UniSTS:508422

Wnt7a (e-PCR), detects polymorphism
- UniSTS:508423

Wnt7a (e-PCR), detects polymorphism
- UniSTS:465425

Wnt7a (e-PCR), detects polymorphism
- UniSTS:526101

Wnt7a (e-PCR), detects polymorphism
- UniSTS:471329

Wnt7a (e-PCR), detects polymorphism
- UniSTS:527143

BE106651 (e-PCR)
- UniSTS:246359

AI849442 (e-PCR)
- UniSTS:165478

BB445750 (e-PCR)
- UniSTS:207996

Wnt7a (e-PCR), detects polymorphism
- UniSTS:277887

Wnt7a (e-PCR), detects polymorphism
- UniSTS:144783

Wnt7a (e-PCR), detects polymorphism
- UniSTS:144784

Wnt7a (e-PCR), detects polymorphism
- UniSTS:516496

Wnt7a (e-PCR), detects polymorphism
- UniSTS:507323

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within asymmetric protein localization involved in cell fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cartilage condensation	IEA Inferred from Electronic Annotation more info
involved_in cartilage condensation	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell proliferation in forebrain	IEA Inferred from Electronic Annotation more info
involved_in cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebellar granule cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic axis specification	IEA Inferred from Electronic Annotation more info
involved_in embryonic axis specification	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of blood-brain barrier	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in limb development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oviduct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation involved in wound healing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axon diameter	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive structure development	IMP Inferred from Mutant Phenotype more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to estrogen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary palate development	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within skeletal muscle satellite cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within skin morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within somatic stem cell division	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell development	IEA Inferred from Electronic Annotation more info
involved_in stem cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uterus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Wnt-7a

Names: postaxial hemimelia; wingless-related MMTV integration site 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363757.1 → NP_001350686.1 protein Wnt-7a isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC121990, AC161456

Conserved Domains (1) summary

cl19568
Location:40 → 145

wnt; wnt family
NM_009527.4 → NP_033553.2 protein Wnt-7a isoform 1 precursor

See identical proteins and their annotated locations for NP_033553.2

Status: VALIDATED

Source sequence(s)

AK004683, BC057586

Consensus CDS

CCDS39568.1

UniProtKB/Swiss-Prot

P24383, Q80VH3, Q9DBY3

Related

ENSMUSP00000032180.7, ENSMUST00000032180.7

Conserved Domains (1) summary

cd19349
Location:32 → 349

Wnt_Wnt7a; Wnt domain found in protein Wnt-7a and similar proteins

RNA

NR_177083.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121990, AC161456

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

91340963..91388335 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166027.1 → XP_036021920.1 protein Wnt-7a isoform X1

Conserved Domains (1) summary

cl38924
Location:1 → 282

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family