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    Lipi lipase, member I [ Mus musculus (house mouse) ]

    Gene ID: 320355, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lipiprovided by MGI
    Official Full Name
    lipase, member Iprovided by MGI
    Primary source
    MGI:MGI:2443868
    See related
    Ensembl:ENSMUSG00000032948 AllianceGenome:MGI:2443868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lpd1; D930038D03Rik
    Summary
    Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in mandible and maxilla. Orthologous to human LIPI (lipase I). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 1.9) See more
    Orthologs
    human all
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    Genomic context

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    See Lipi in Genome Data Viewer
    Location:
    16 C3.1; 16 43.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (75337431..75382960, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (75540514..75586072, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 2 Neighboring gene STARR-seq mESC enhancer starr_41263 Neighboring gene STARR-seq mESC enhancer starr_41264 Neighboring gene predicted gene, 52278 Neighboring gene STARR-seq mESC enhancer starr_41265 Neighboring gene STARR-seq mESC enhancer starr_41266 Neighboring gene STARR-seq mESC enhancer starr_41267 Neighboring gene nuclear encoded tRNA isoleucine 1 (anticodon AAT) Neighboring gene STARR-seq mESC enhancer starr_41269 Neighboring gene RNA binding motif protein 11 Neighboring gene predicted gene, 41474 Neighboring gene predicted gene, 30162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Wen XY, et al. Hum Mol Genet, 2003 May 15. PMID 12719377
    2. Characterization of lpd (lipid defect): a novel mutation on mouse chromosome 16 associated with a defect in triglyceride metabolism. Wen XY, et al. Hum Mol Genet, 1998 Apr. PMID 9499429
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lipase member I
    NP_001239442.1
    XP_011244435.1
    XP_011244436.1
    XP_011244437.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252513.2 → NP_001239442.1  lipase member I

      See identical proteins and their annotated locations for NP_001239442.1

      Status: VALIDATED

      Source sequence(s)
      AC129186, AC166995
      Consensus CDS
      CCDS28272.2
      UniProtKB/TrEMBL
      F6YQT7
      Related
      ENSMUSP00000053447.11, ENSMUST00000062721.11
      Conserved Domains (1) summary
      cd00707
      Location:57 → 346
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      75337431..75382960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246134.1 → XP_011244436.1  lipase member I isoform X2

      Conserved Domains (1) summary
      cd00707
      Location:57 → 346
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    2. XM_011246135.1 → XP_011244437.1  lipase member I isoform X3

      Conserved Domains (1) summary
      cd00707
      Location:41 → 330
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    3. XM_011246133.1 → XP_011244435.1  lipase member I isoform X1

      Conserved Domains (1) summary
      cd00707
      Location:57 → 346
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177142.4: Suppressed sequence

      Description
      NM_177142.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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