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    Aopep aminopeptidase O [ Mus musculus (house mouse) ]

    Gene ID: 72061, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Aopepprovided by MGI
    Official Full Name
    aminopeptidase Oprovided by MGI
    Primary source
    MGI:MGI:1919311
    See related
    Ensembl:ENSMUSG00000021458 AllianceGenome:MGI:1919311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ApO; AP-O; mir-23b; mir-27b; mir-24-1; 2010111I01Rik; 2300006M17Rik
    Summary
    Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Located in nucleolus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut gland; and liver and biliary system. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.3), limb E14.5 (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aopep in Genome Data Viewer
    Location:
    13 B3; 13 32.8 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63112707..63473910)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62964893..63326096)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34785 Neighboring gene STARR-seq mESC enhancer starr_34786 Neighboring gene predicted gene, 38679 Neighboring gene fructose bisphosphatase 1 Neighboring gene predicted gene, 40981 Neighboring gene STARR-positive B cell enhancer ABC_E7247 Neighboring gene tubulin, beta 2a, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_34787 Neighboring gene predicted gene, 46422 Neighboring gene predicted gene, 30409 Neighboring gene STARR-seq mESC enhancer starr_34791 Neighboring gene STARR-seq mESC enhancer starr_34792 Neighboring gene microRNA 3074-1 Neighboring gene STARR-positive B cell enhancer mm9_chr13:63433953-63434254 Neighboring gene predicted gene, 16907 Neighboring gene STARR-seq mESC enhancer starr_34797 Neighboring gene microRNA 24-1 Neighboring gene microRNA 23b Neighboring gene microRNA 27b Neighboring gene Fanconi anemia, complementation group C Neighboring gene STARR-seq mESC enhancer starr_34799 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:63532981-63533164 Neighboring gene STARR-seq mESC enhancer starr_34801 Neighboring gene STARR-seq mESC enhancer starr_34802 Neighboring gene Ptch1 Hedgehog-responsive enhancers Neighboring gene patched 1 Neighboring gene STARR-seq mESC enhancer starr_34806 Neighboring gene predicted gene, 30655

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting CCL7. Zhang Y, et al. Mol Ther, 2018 Feb 7. PMID 29275848, Free PMC Article
    2. MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes. Shen L, et al. PLoS One, 2016. PMID 26849429, Free PMC Article
    3. Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue. Kong X, et al. Diabetes, 2015 Feb. PMID 25187367, Free PMC Article
    4. Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice. Jiang YH, et al. Int J Mol Sci, 2021 Jan 7. PMID 33430468, Free PMC Article
    5. miRNA-27b modulates endothelial cell angiogenesis by directly targeting Naa15 in atherogenesis. Qun L, et al. Atherosclerosis, 2016 Nov. PMID 27755984

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice.
      Title: Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice.
    2. our results characterize a novel aspect of miR-23b function in leukocyte migration, and they identify miR-23b as a potential therapeutic target in the amelioration of MS and likely other autoimmune diseases.
      Title: miR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting CCL7.
    3. decreased miRNA-27b regulates the activity of the CCL20/CCR6 axis by targeting Naa15, and promotes plaque stability in atherosclerosis
      Title: miRNA-27b modulates endothelial cell angiogenesis by directly targeting Naa15 in atherogenesis.
    4. MiRNA-27b regulates mitochondria biogenesis in myocytes by down-regulation of Foxj3 during myocyte differentiation.
      Title: MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes.
    5. These results indicate that miR-27b functions as a central target of glucocorticoids and as an upstream regulator of Prdm16.
      Title: Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue.
    6. Alternative splicing predictably produces protein products with or without the catalytic domain and/or a nucleolar localisation signal and represents mechanism in regulating activity of APO.
      Title: Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289924.1 → NP_001276853.1  aminopeptidase O

      See identical proteins and their annotated locations for NP_001276853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154382, AK044477, CT009757
      Consensus CDS
      CCDS36699.1
      UniProtKB/Swiss-Prot
      Q3UQZ7, Q6P0W6, Q6P394, Q8BHX5, Q8BXQ6
      UniProtKB/TrEMBL
      A0A1Y7VJQ6
      Related
      ENSMUSP00000152528.2, ENSMUST00000220863.2
      Conserved Domains (2) summary
      pfam09127
      Location:710 → 822
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:244 → 641
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    2. NM_001289926.1 → NP_001276855.1  aminopeptidase O

      See identical proteins and their annotated locations for NP_001276855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 3' UTR. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK044477, AK141931, BX520155, CT009757
      Consensus CDS
      CCDS36699.1
      UniProtKB/Swiss-Prot
      Q3UQZ7, Q6P0W6, Q6P394, Q8BHX5, Q8BXQ6
      UniProtKB/TrEMBL
      A0A1Y7VJQ6
      Related
      ENSMUSP00000089148.5, ENSMUST00000091560.11
      Conserved Domains (2) summary
      pfam09127
      Location:710 → 822
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:244 → 641
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RNA

    1. NR_110520.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      CT009757

    2. NR_110521.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' and 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC130827, AK076298, CT009757
      Related
      ENSMUST00000159152.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      63112707..63473910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028079.2: Suppressed sequence

      Description
      NM_028079.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXQ6.3 GenPept UniProtKB/Swiss-Prot:Q8BXQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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