Ncapg non-SMC condensin I complex, subunit G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncapgprovided by MGI
Official Full Name: non-SMC condensin I complex, subunit Gprovided by MGI
Primary source: MGI:MGI:1930197
See related: Ensembl:ENSMUSG00000015880 AllianceGenome:MGI:1930197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hcapg; MFT.M05.13; 5730507H05Rik
Summary: Predicted to be involved in mitotic chromosome condensation and positive regulation of chromosome condensation. Located in condensed chromosome, centromeric region and cytoplasm. Part of condensin complex. Is expressed in several structures, including lung; metanephros; nose; tooth; and ventricular layer. Orthologous to human NCAPG (non-SMC condensin I complex subunit G). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14 (RPKM 14.6), CNS E11.5 (RPKM 13.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 25.23 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (45827212..45858491)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (45669891..45700547)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nonstructural maintenance of chromatin condensin I complex subunit G promotes the progression of glioblastoma by facilitating Poly (ADP-ribose) polymerase 1-mediated E2F1 transactivation.
Title: Nonstructural maintenance of chromatin condensin I complex subunit G promotes the progression of glioblastoma by facilitating Poly (ADP-ribose) polymerase 1-mediated E2F1 transactivation.
NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN.
Title: NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome condensation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	ISO Inferred from Sequence Orthology more info
part_of condensin complex	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: condensin complex subunit 3

Names: chromosome condensation protein G; on-SMC condensin I complex, subunit G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019438.2 → NP_062311.1 condensin complex subunit 3

Status: VALIDATED

Source sequence(s)

AC093341

Consensus CDS

CCDS51498.1

UniProtKB/TrEMBL

E9PWG6

Related

ENSMUSP00000112871.2, ENSMUST00000117396.3

Conserved Domains (3) summary

pfam12719
Location:557 → 859

Cnd3; Nuclear condensing complex subunits, C-term domain

pfam13646
Location:103 → 204

HEAT_2; HEAT repeats

sd00044
Location:212 → 234

HEAT; HEAT repeat [structural motif]