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    Agr3 anterior gradient 3 [ Mus musculus (house mouse) ]

    Gene ID: 403205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agr3provided by MGI
    Official Full Name
    anterior gradient 3provided by MGI
    Primary source
    MGI:MGI:2685734
    See related
    Ensembl:ENSMUSG00000036231 AllianceGenome:MGI:2685734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm888; BCMP11; E030025L21Rik
    Summary
    Predicted to enable dystroglycan binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum. Orthologous to human AGR3 (anterior gradient 3, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Agr3 in Genome Data Viewer
    Location:
    12 A3; 12 15.97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (35975620..35999736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (35925621..35949737)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:36525891-36526191 Neighboring gene predicted gene 9472 Neighboring gene STARR-seq mESC enhancer starr_31911 Neighboring gene STARR-seq mESC enhancer starr_31913 Neighboring gene anterior gradient 2 Neighboring gene tetraspanin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10744 Neighboring gene STARR-positive B cell enhancer ABC_E2382

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway. Bonser LR, et al. Am J Respir Cell Mol Biol, 2015 Oct. PMID 25751668, Free PMC Article
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dystroglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dystroglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anterior gradient protein 3
    Names
    anterior gradient homolog 3
    anterior gradient protein 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207531.3 → NP_997414.2  anterior gradient protein 3 precursor

      See identical proteins and their annotated locations for NP_997414.2

      Status: VALIDATED

      Source sequence(s)
      AK053177, AW490945, BE650904
      Consensus CDS
      CCDS25880.1
      UniProtKB/Swiss-Prot
      A7NSI1, Q8BW95, Q8R3W7
      Related
      ENSMUSP00000049212.5, ENSMUST00000042101.5
      Conserved Domains (1) summary
      cd02960
      Location:36 → 165
      AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      35975620..35999736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515142.4 → XP_006515205.1  anterior gradient protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006515205.1

      Conserved Domains (1) summary
      cl00388
      Location:1 → 104
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. XM_006515143.1 → XP_006515206.1  anterior gradient protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006515206.1

      Conserved Domains (1) summary
      cl00388
      Location:1 → 104
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3W7.1 GenPept UniProtKB/Swiss-Prot:Q8R3W7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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