Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcg2provided by MGI
Official Full Name: ATP binding cassette subfamily G member 2 (Junior blood group)provided by MGI
Primary source: MGI:MGI:1347061
See related: Ensembl:ENSMUSG00000029802 AllianceGenome:MGI:1347061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1
Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]
Expression: Broad expression in kidney adult (RPKM 44.7), placenta adult (RPKM 44.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.82 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (58561476..58669436)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (58584491..58692451)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Title: ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Nongenomic ERalpha-AMPK Signaling Regulates Sex-Dependent Bcrp Transport Activity at the Blood-Brain Barrier.
Title: Nongenomic ERα-AMPK Signaling Regulates Sex-Dependent Bcrp Transport Activity at the Blood-Brain Barrier.
The ABCG2 protein in vitro transports the xenobiotic thiabendazole and increases the appearance of its residues in milk.
Title: The ABCG2 protein in vitro transports the xenobiotic thiabendazole and increases the appearance of its residues in milk.
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Title: ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier.
Title: Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier.
GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms.
Title: GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms.
BCRP drives intrinsic chemoresistance in chemotherapy-naive breast cancer brain metastasis.
Title: BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.
Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1beta production in murine macrophage-like J774.1 cells.
Title: Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1β production in murine macrophage-like J774.1 cells.
Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
Title: Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBalpha.
Title: Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.

Submit: New GeneRIF Correction See all GeneRIFs (130)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (8) 1 citation

General gene information

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Markers

AI428558 (e-PCR)
- UniSTS:159513

Abcg2 (e-PCR), detects polymorphism
- UniSTS:546618

UniSTS:225011 (e-PCR)
- UniSTS:225011

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables biotin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables riboflavin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables riboflavin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biotin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in renal urate salt excretion	ISO Inferred from Sequence Orthology more info
involved_in renal urate salt excretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in riboflavin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in riboflavin transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate transport	IEA Inferred from Electronic Annotation more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: broad substrate specificity ATP-binding cassette transporter ABCG2

Names: ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; breast cancer resistance protein 1 homolog; mitoxantrone resistance protein 1; urate exporter

NP_001342406.1

EC 7.6.2.2

NP_001368854.1

EC 7.6.2.2

NP_001368855.1

EC 7.6.2.2

NP_001368856.1

EC 7.6.2.2

NP_036050.1

EC 7.6.2.2

XP_006506213.1

EC 7.6.2.2

XP_011239664.1

EC 7.6.2.2

XP_030111259.1

EC 7.6.2.2

XP_030111260.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355477.2 → NP_001342406.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Status: VALIDATED

Source sequence(s)

AC121855, AC121859

Consensus CDS

CCDS20195.1

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
NM_001381925.1 → NP_001368854.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Status: VALIDATED

Source sequence(s)

AC121855, AC121859

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
NM_001381926.1 → NP_001368855.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Status: VALIDATED

Source sequence(s)

AC121855, AC121859

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
NM_001381927.1 → NP_001368856.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Status: VALIDATED

Source sequence(s)

AC121859

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Related

ENSMUSP00000109933.2, ENSMUST00000114294.8

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
NM_011920.3 → NP_036050.1 broad substrate specificity ATP-binding cassette transporter ABCG2

See identical proteins and their annotated locations for NP_036050.1

Status: VALIDATED

Source sequence(s)

AC121855, AC121859, AF103875, AI428558, AK087830, CO039662

Consensus CDS

CCDS20195.1

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Related

ENSMUSP00000031822.7, ENSMUST00000031822.13

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

58561476..58669436

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241362.1 → XP_011239664.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

See identical proteins and their annotated locations for XP_011239664.1

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
XM_030255399.2 → XP_030111259.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
XM_030255400.1 → XP_030111260.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
XM_006506150.5 → XP_006506213.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

See identical proteins and their annotated locations for XP_006506213.1

UniProtKB/Swiss-Prot

Q7TMS5, Q9R004, Q9Z1T0

UniProtKB/TrEMBL

A0A0R4J0B6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein