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    Alg2 ALG2 alpha-1,3/1,6-mannosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 56737, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Alg2provided by MGI
    Official Full Name
    ALG2 alpha-1,3/1,6-mannosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1914731
    See related
    Ensembl:ENSMUSG00000039740 AllianceGenome:MGI:1914731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALPG2; CDGIi; MNCb-5081; 1110018A23Rik; 1300013N08Rik
    Summary
    Predicted to enable GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 51.1), CNS E18 (RPKM 41.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg2 in Genome Data Viewer
    Location:
    4 B1; 4 26.03 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (47469833..47474367, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (47469833..47474367, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32435 Neighboring gene transforming growth factor, beta receptor I Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47438228-47438411 Neighboring gene STARR-seq mESC enhancer starr_10143 Neighboring gene microfibrillar-associated protein 1B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3491 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47487387-47487624 Neighboring gene SEC61 translocon subunit beta Neighboring gene predicted gene, 42283

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ALG-2 divalent-ion affinity: Calorimetric analysis of the des23 versions reveals high-affinity site for Mg(2). Henzl MT, et al. Biophys Chem, 2016 Feb. PMID 26705706
    2. Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. Imamura K, et al. J Biol Chem, 2014 Apr 4. PMID 24563464, Free PMC Article
    3. The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. Draeby I, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17889823, Free PMC Article
    4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the observation that both ALG-2 isoforms bind Mg2+ with high affinity is the most significant finding of this study
      Title: ALG-2 divalent-ion affinity: Calorimetric analysis of the des23 versions reveals high-affinity site for Mg(2).
    2. Thus, Alg2, as a downstream mediator of Hivep3, suppresses osteogenesis, whereas it promotes chondrogenesis.
      Title: Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.
    3. ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways
      Title: The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3/1,6-mannosyltransferase ALG2
    Names
    GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
    GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
    GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
    alpha-1,3-mannosyltransferase ALG2
    asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation protein 2 homolog
    NP_001342425.1
    NP_064382.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355496.1 → NP_001342425.1  alpha-1,3/1,6-mannosyltransferase ALG2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AI834815, BC052411, BU612370, BY129752
      Conserved Domains (1) summary
      cl10013
      Location:67 → 334
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    2. NM_019998.3 → NP_064382.3  alpha-1,3/1,6-mannosyltransferase ALG2 isoform 1

      See identical proteins and their annotated locations for NP_064382.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC052411, BG093758, BY129752
      Consensus CDS
      CCDS18161.1
      UniProtKB/Swiss-Prot
      Q7TN30, Q9CWI6, Q9DBE8, Q9JJA8
      Related
      ENSMUSP00000043580.3, ENSMUST00000044148.3
      Conserved Domains (1) summary
      cd03805
      Location:17 → 407
      GT4_ALG2-like; alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      47469833..47474367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBE8.2 GenPept UniProtKB/Swiss-Prot:Q9DBE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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