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    MKRN4P makorin ring finger protein 4, pseudogene [ Homo sapiens (human) ]

    Gene ID: 7682, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MKRN4Pprovided by HGNC
    Official Full Name
    makorin ring finger protein 4, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:7115
    See related
    AllianceGenome:HGNC:7115
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKRN4; RNF64; MKRNP5; ZNF-Xp; ZNF127L1; ZNF127-Xp
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MKRN4P in Genome Data Viewer
    Location:
    Xp11.4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (40834254..40837807)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (40235461..40239014)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (40693507..40697060)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CLDN7 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:40676071-40676572 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40693428-40693928 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40693929-40694429 Neighboring gene TNIP2 pseudogene 1 Neighboring gene hESC enhancers GRCh37_chrX:40703903-40704854 and GRCh37_chrX:40704855-40705806 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:40710515-40711082 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40712217-40712784 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40712785-40713352 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40726337-40726836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29552 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40737647-40738520 Neighboring gene syndecan binding protein pseudogene 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:40767632-40768831 Neighboring gene ribosomal protein L32 pseudogene 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Van Quickelberghe E, et al. Sci Data, 2018 Dec 18. PMID 30561431, Free PMC Article
    2. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article
    3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • makorin ring finger protein pseudogene 5
    • makorin, ring finger protein, 4
    • zinc finger protein 127-like 1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_004713.4 

      Range
      101..3654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      40834254..40837807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      40235461..40239014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030757.1: Suppressed sequence

      Description
      NM_030757.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13434.1 GenPept UniProtKB/Swiss-Prot:Q13434

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.