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    Cx3cl1 C-X3-C motif chemokine ligand 1 [ Mus musculus (house mouse) ]

    Gene ID: 20312, updated on 13-Jan-2025

    Summary

    Official Symbol
    Cx3cl1provided by MGI
    Official Full Name
    C-X3-C motif chemokine ligand 1provided by MGI
    Primary source
    MGI:MGI:1097153
    See related
    Ensembl:ENSMUSG00000031778 AllianceGenome:MGI:1097153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FK; CX3C; Cxc3; Scyd1; ABCD-3; D8Bwg0439e
    Summary
    Enables CX3C chemokine receptor binding activity. Acts upstream of or within several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of transforming growth factor beta1 production. Located in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; nose; and respiratory system. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in cortex adult (RPKM 170.7), frontal lobe adult (RPKM 132.2) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Cx3cl1 in Genome Data Viewer
    Location:
    8 C5; 8 46.79 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95498808..95509055)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94772180..94782427)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 22 Neighboring gene guanine nucleotide binding protein (G protein), beta 1, pseudogene 3 Neighboring gene predicted gene, 51543 Neighboring gene RIKEN cDNA 1700121C10 gene Neighboring gene C-C motif chemokine ligand 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding  
    enables CX3C chemokine receptor binding PubMed 
    enables CX3C chemokine receptor binding  
    enables CX3C chemokine receptor binding  
    enables CXCR1 chemokine receptor binding  
    enables CXCR1 chemokine receptor binding  
    enables chemoattractant activity  
    enables chemoattractant activity  
    enables chemokine activity  
    enables chemokine activity  
    enables integrin binding  
    enables integrin binding  
    Items 1 - 25 of 76
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within angiogenesis involved in wound healing PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in autocrine signaling  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell chemotaxis  
    involved_in cell-cell adhesion  
    involved_in cellular response to tumor necrosis factor  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemotaxis  
    involved_in chemotaxis  
    acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
    involved_in eosinophil chemotaxis  
    acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    involved_in immune response  
    involved_in inflammatory response  
    involved_in inhibitory postsynaptic potential  
    involved_in integrin activation  
    involved_in integrin activation  
    involved_in leukocyte migration involved in inflammatory response  
    involved_in leukocyte migration involved in inflammatory response  
    acts_upstream_of_or_within lymphocyte chemotaxis PubMed 
    involved_in microglial cell activation  
    involved_in microglial cell proliferation  
    involved_in microglial cell proliferation  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    involved_in negative regulation of glutamate receptor signaling pathway  
    involved_in negative regulation of hippocampal neuron apoptotic process  
    involved_in negative regulation of hippocampal neuron apoptotic process  
    involved_in negative regulation of interleukin-1 alpha production  
    involved_in negative regulation of microglial cell activation  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of vasoconstriction  
    involved_in neuron cellular homeostasis  
    acts_upstream_of_or_within neutrophil chemotaxis PubMed 
    involved_in positive chemotaxis  
    involved_in positive chemotaxis  
    involved_in positive regulation of I-kappaB phosphorylation  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of actin filament bundle assembly  
    involved_in positive regulation of actin filament bundle assembly  
    involved_in positive regulation of calcium-independent cell-cell adhesion  
    involved_in positive regulation of calcium-independent cell-cell adhesion  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of macrophage chemotaxis  
    involved_in positive regulation of microglial cell migration  
    involved_in positive regulation of microglial cell migration  
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transforming growth factor beta1 production PubMed 
    involved_in regulation of lipopolysaccharide-mediated signaling pathway  
    involved_in regulation of lipopolysaccharide-mediated signaling pathway  
    involved_in response to ischemia  
    acts_upstream_of_or_within wound healing PubMed 
    Items 1 - 25 of 76
    Component Evidence Code Pubs
    located_in cell body PubMed 
    located_in cell projection  
    located_in cell surface  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in membrane  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    fractalkine
    Names
    C-X3-C motif chemokine 1
    CX3C membrane-anchored chemokine
    chemokine (C-X3-C motif) ligand 1
    neurotactin
    small inducible cytokine subfamily D, 1
    small-inducible cytokine D1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009142.3NP_033168.2  fractalkine precursor

      See identical proteins and their annotated locations for NP_033168.2

      Status: VALIDATED

      Source sequence(s)
      AC123826, AK138214, CB526167
      Consensus CDS
      CCDS22548.1
      UniProtKB/Swiss-Prot
      O35188, O35933, Q91V44
      UniProtKB/TrEMBL
      Q8C9Y1
      Related
      ENSMUSP00000034230.6, ENSMUST00000034230.7
      Conserved Domains (1) summary
      cd00274
      Location:25100
      Chemokine_CX3C; Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95498808..95509055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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