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    Mier1 MIER1 transcriptional regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mier1provided by RGD
    Official Full Name
    MIER1 transcriptional regulatorprovided by RGD
    Primary source
    RGD:1562337
    See related
    EnsemblRapid:ENSRNOG00000007175 AllianceGenome:RGD:1562337
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562337
    Summary
    Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in chromatin remodeling; negative regulation of transcription by RNA polymerase II; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Orthologous to human MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 259.3), Spleen (RPKM 156.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mier1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (123105114..123156653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (117876012..117927592)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (122642065..122693642)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene insulin like 5 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene solute carrier family 35 member D1 Neighboring gene similar to human chromosome 1 open reading frame 141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. Ding Z, et al. Mol Cell Biol, 2003 Jan. PMID 12482978, Free PMC Article
    2. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
    3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188399

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mesoderm induction early response protein 1
    Names
    mesoderm induction early response 1 homolog
    mesoderm induction early response 1, transcriptional regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131012.1 → NP_001124484.1  mesoderm induction early response protein 1

      See identical proteins and their annotated locations for NP_001124484.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168252
      UniProtKB/TrEMBL
      B4F7F2, E9PT68
      Related
      ENSRNOP00000063001.1, ENSRNOT00000066041.3
      Conserved Domains (3) summary
      smart00717
      Location:288 → 333
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:288 → 332
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:182 → 231
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      123105114..123156653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593373.3 → XP_017448862.1  mesoderm induction early response protein 1 isoform X2

      Related
      ENSRNOP00000085059.2, ENSRNOT00000095676.2

    2. XM_017593374.3 → XP_017448863.1  mesoderm induction early response protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0V9

    3. XM_006238479.4 → XP_006238541.1  mesoderm induction early response protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZWG7
      Related
      ENSRNOP00000081443.2, ENSRNOT00000099770.2
      Conserved Domains (3) summary
      smart00717
      Location:437 → 482
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:437 → 481
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:331 → 380
      ELM2; ELM2 domain

    4. XM_063287698.1 → XP_063143768.1  mesoderm induction early response protein 1 isoform X13

    5. XM_063287696.1 → XP_063143766.1  mesoderm induction early response protein 1 isoform X11

      UniProtKB/TrEMBL
      E9PT68

    6. XM_039109957.2 → XP_038965885.1  mesoderm induction early response protein 1 isoform X5

      UniProtKB/TrEMBL
      E9PT68
      Conserved Domains (2) summary
      cd11661
      Location:287 → 331
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:181 → 230
      ELM2; ELM2 domain

    7. XM_017593381.3 → XP_017448870.1  mesoderm induction early response protein 1 isoform X1

      UniProtKB/TrEMBL
      E9PT68
      Conserved Domains (2) summary
      cd11661
      Location:324 → 368
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:218 → 267
      ELM2; ELM2 domain

    8. XM_039109952.2 → XP_038965880.1  mesoderm induction early response protein 1 isoform X3

      UniProtKB/TrEMBL
      E9PT68
      Conserved Domains (2) summary
      cd11661
      Location:311 → 355
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:205 → 254
      ELM2; ELM2 domain

    9. XM_063287693.1 → XP_063143763.1  mesoderm induction early response protein 1 isoform X7

    10. XM_063287694.1 → XP_063143764.1  mesoderm induction early response protein 1 isoform X8

    11. XM_063287697.1 → XP_063143767.1  mesoderm induction early response protein 1 isoform X12

    12. XM_039109951.2 → XP_038965879.1  mesoderm induction early response protein 1 isoform X9

      UniProtKB/TrEMBL
      E9PT68
      Conserved Domains (2) summary
      cd11661
      Location:321 → 365
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:215 → 264
      ELM2; ELM2 domain

    13. XM_063287695.1 → XP_063143765.1  mesoderm induction early response protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZSL3, A6JRS4, E9PT68

    14. XM_039109948.2 → XP_038965876.1  mesoderm induction early response protein 1 isoform X1

      UniProtKB/TrEMBL
      E9PT68
      Conserved Domains (2) summary
      cd11661
      Location:324 → 368
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:218 → 267
      ELM2; ELM2 domain

    15. XM_039109956.2 → XP_038965884.1  mesoderm induction early response protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZSL3, A6JRS4, E9PT68
      Conserved Domains (2) summary
      cd11661
      Location:305 → 349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199 → 248
      ELM2; ELM2 domain

    16. XM_063287701.1 → XP_063143771.1  mesoderm induction early response protein 1 isoform X15

      UniProtKB/TrEMBL
      E9PT68

    17. XM_063287700.1 → XP_063143770.1  mesoderm induction early response protein 1 isoform X5

      UniProtKB/TrEMBL
      E9PT68

    18. XM_063287703.1 → XP_063143773.1  mesoderm induction early response protein 1 isoform X17

    19. XM_063287699.1 → XP_063143769.1  mesoderm induction early response protein 1 isoform X14

      UniProtKB/TrEMBL
      E9PT68

    20. XM_063287702.1 → XP_063143772.1  mesoderm induction early response protein 1 isoform X16

      UniProtKB/TrEMBL
      E9PT68
    Nucleotide Protein Strain
    Heading Accession and Version

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