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    Cmtr1 cap methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309656, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cmtr1provided by RGD
    Official Full Name
    cap methyltransferase 1provided by RGD
    Primary source
    RGD:1307801
    See related
    EnsemblRapid:ENSRNOG00000000532 AllianceGenome:RGD:1307801
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MTr1; Ftsjd2; LRRG00129; RGD1307801
    Summary
    Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 208.9), Adrenal (RPKM 195.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmtr1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7724286..7784787)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7722729..7782579)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (8324968..8385174)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 22B Neighboring gene ring finger protein 8 Neighboring gene coiled-coil domain containing 167 Neighboring gene ribosomal protein S15, pseudogene 19 Neighboring gene ribosomal protein S20 like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. Bélanger F, et al. J Biol Chem, 2010 Oct 22. PMID 20713356, Free PMC Article
    2. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Werner M, et al. Nucleic Acids Res, 2011 Jun. PMID 21310715, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Names
    FtsJ methyltransferase domain containing 2
    S-adenosyl-L-methionine-dependent methyltransferase FTSJD2
    cap1 2'O-ribose methyltransferase 1
    ftsJ methyltransferase domain-containing protein 2
    NP_001014053.1
    XP_038954644.1
    XP_038954645.1
    XP_038954646.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014031.1 → NP_001014053.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

      See identical proteins and their annotated locations for NP_001014053.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085799
      UniProtKB/Swiss-Prot
      Q5U2Z5
      UniProtKB/TrEMBL
      A0A8I6AHL4, A6JJV9
      Related
      ENSRNOP00000080385.1, ENSRNOT00000101461.2
      Conserved Domains (3) summary
      pfam01585
      Location:86 → 128
      G-patch; G-patch domain
      pfam01728
      Location:231 → 447
      FtsJ; FtsJ-like methyltransferase
      cl12015
      Location:622 → 739
      Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7724286..7784787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098717.2 → XP_038954645.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIF5
      Related
      ENSRNOP00000081353.2, ENSRNOT00000111387.2
      Conserved Domains (3) summary
      pfam01585
      Location:86 → 128
      G-patch; G-patch domain
      pfam01728
      Location:231 → 447
      FtsJ; FtsJ-like methyltransferase
      cl12015
      Location:622 → 739
      Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

    2. XM_039098718.2 → XP_038954646.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X3

      Conserved Domains (2) summary
      pfam01585
      Location:86 → 128
      G-patch; G-patch domain
      cl17173
      Location:231 → 368
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_039098716.2 → XP_038954644.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z5
      UniProtKB/TrEMBL
      A0A8I6AHL4, A6JJV9
      Conserved Domains (3) summary
      pfam01585
      Location:86 → 128
      G-patch; G-patch domain
      pfam01728
      Location:231 → 447
      FtsJ; FtsJ-like methyltransferase
      cl12015
      Location:622 → 739
      Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2Z5.1 GenPept UniProtKB/Swiss-Prot:Q5U2Z5

    Gene LinkOut

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