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    Eef1g eukaryotic translation elongation factor 1 gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293725, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eef1gprovided by RGD
    Official Full Name
    eukaryotic translation elongation factor 1 gammaprovided by RGD
    Primary source
    RGD:1302939
    See related
    EnsemblRapid:ENSRNOG00000020075 AllianceGenome:RGD:1302939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in response to virus and translational elongation. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 2690.0), Spleen (RPKM 2395.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eef1g in Genome Data Viewer
    Location:
    1q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215289815..215300421)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205860713..205871319)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225163391..225173997)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 family, member 2 Neighboring gene uncharacterized LOC134483968 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene AHNAK nucleoprotein Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. Sanders J, et al. J Cell Sci, 1996 May. PMID 8743958
    2. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Leong WF, et al. Cell Microbiol, 2006 Apr. PMID 16548883, Free PMC Article
    3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
    4. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. Chen VC, et al. J Proteome Res, 2012 Dec 7. PMID 23106098
    5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94929, MGC114210

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 1-gamma
    Names
    EF-1-gamma
    eEF-1B gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004223.2 → NP_001004223.1  elongation factor 1-gamma

      See identical proteins and their annotated locations for NP_001004223.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098895
      UniProtKB/Swiss-Prot
      Q4FZZ5, Q68FR6
      UniProtKB/TrEMBL
      A0A8I6AK06, A6HZY2
      Related
      ENSRNOP00000027305.4, ENSRNOT00000027305.9
      Conserved Domains (4) summary
      cd03181
      Location:91 → 213
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      cd03044
      Location:4 → 82
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      TIGR01262
      Location:5 → 187
      maiA; maleylacetoacetate isomerase
      pfam00647
      Location:275 → 381
      EF1G; Elongation factor 1 gamma, conserved domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215289815..215300421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FR6.3 GenPept UniProtKB/Swiss-Prot:Q68FR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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