Steap1 STEAP family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Steap1provided by RGD
Official Full Name: STEAP family member 1provided by RGD
Primary source: RGD:1311543
See related: EnsemblRapid:ENSRNOG00000000017 AllianceGenome:RGD:1311543
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Steap
Summary: Predicted to enable heme binding activity. Predicted to be active in endosome and plasma membrane. Orthologous to several human genes including STEAP1 (STEAP family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 58.2), Uterus (RPKM 14.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (29231809..29242317)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (28276972..28287484)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (25435885..25446393)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STEAP1 is down-regulated by dihydrotestosterone and estradiols in LNCaP cells and in rat prostate.
Title: Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables cupric reductase (NADH) activity	ISO Inferred from Sequence Orthology more info
NOT enables ferric-chelate reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
NOT enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within copper ion import	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STEAP1 protein

Names: metalloreductase STEAP1; six transmembrane epithelial antigen of the prostate 1

NP_001100099.1

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.