Fdx1 ferredoxin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fdx1provided by RGD
Official Full Name: ferredoxin 1provided by RGD
Primary source: RGD:62036
See related: AllianceGenome:RGD:62036
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables electron transfer activity; enzyme binding activity; and iron ion binding activity. Contributes to NADPH-adrenodoxin reductase activity and cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including NADPH oxidation; cellular response to epinephrine stimulus; and cellular response to leptin stimulus. Located in mitochondrial crista and mitochondrial matrix. Biomarker of pancreatitis. Orthologous to human FDX1 (ferredoxin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 8606.5) and Liver (RPKM 665.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (61164839..61183645, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (52268536..52287344, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (56373729..56393199, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells.
Title: FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139364 (e-PCR)
- UniSTS:221450

Fdx1 (e-PCR), detects polymorphism
- UniSTS:256610

AI237068 (e-PCR)
- UniSTS:261584

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADPH-adrenodoxin reductase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cholesterol monooxygenase (side-chain-cleaving) activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NADPH oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in P450-containing electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leptin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hormone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidoreductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adrenodoxin, mitochondrial

Names: adrenal ferredoxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017126.2 → NP_058822.2 adrenodoxin, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P24483

UniProtKB/TrEMBL

A6J4I2, G3V7L0

Conserved Domains (1) summary

cl00159
Location:71 → 174

fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...